108138-46-1 Usage
Pharmaceutical Applications
It is active against a wide range of Gram-positive and Gram-negative bacteria, including Acinetobacter spp., L. pneumophila and Campylobacter spp. Unlike many quinolones it is moderately active against L. monocytogenes. C. trachomatis is also moderately susceptible. It is active against some anaerobes, including the B. fragilis group. Activity against Mycobacterium spp. is limited. It is well absorbed by the oral route, achieving a plasma concentration of c. 1 mg/L 4 h after a 300 mg dose. Around 30–35% of the dose is eliminated in the urine, with an apparent elimination half-life of 6–7 h.Clinical experience is limited, but high clinical and bacteriological cure rates have been obtained in patients with skin and soft-tissue infections.
Check Digit Verification of cas no
The CAS Registry Mumber 108138-46-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,1,3 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 108138-46:
(8*1)+(7*0)+(6*8)+(5*1)+(4*3)+(3*8)+(2*4)+(1*6)=111
111 % 10 = 1
So 108138-46-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H15F3N4O3.C7H8O3S/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25;1-6-2-4-7(5-3-6)11(8,9)10/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29);2-5H,1H3,(H,8,9,10)
108138-46-1Relevant articles and documents
Naphthyridine antianaerobic compounds
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, (2008/06/13)
The naphthyridine compounds having the formula: wherein R1 is hydrogen or a carboxy protecting group have unexpected and superior antianaerobic activity.