1081112-26-6

Basic information

• Product Name: 2-(thiazol-4-yl)-1-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-1H-benzimidazole
• Synonyms: 2-(thiazol-4-yl)-1-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-1H-benzimidazole
• CAS NO: 1081112-26-6
• Molecular Weight: 459.615
• Mol File: 1081112-26-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(thiazol-4-yl)-1-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(thiazol-4-yl)-1-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-1H-benzimidazole(1081112-26-6)
• EPA Substance Registry System: 2-(thiazol-4-yl)-1-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-1H-benzimidazole(1081112-26-6)

Safety Data

• Hazardous Substances Data: 1081112-26-6(Hazardous Substances Data)

Upstream product

• 1081112-32-4 3-[4-(3-acetylaminophenyl)piperidin-1-yl]propan-1-ol 
• 486430-92-6 N₁-(3-(piperidin-4-yl)phenyl)acetamide hydrochloride 
• 95-54-5 1,2-diamino-benzene 
• 1081112-34-6 3-[4-(3-acetylaminophenyl)piperidin-1-yl]propyl methanesulfonate 
• 148-79-8 thiabendazole 

Relevant articles and documents

2-heteroaryl benzimidazole derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists

A novel series of 2-heteroaryl substituted benzimidazole derivatives, containing the piperidinylphenyl acetamide group at the 1-position, were synthesized and evaluated as MCH-R1 antagonists. Extensive SAR investigation probing the effects of C-2 heteroaryl group led to the identification of 2-[2-(pyridin-3-yl)ethyl] analog 3o, which exhibits highly potent MCH-R1 binding activity with an IC50 value of 1 nM. This substance 3o also has low hERG binding activity, good metabolic stability, and favorable pharmacokinetic properties.