1081-09-0

Basic information

• Product Name: 3 5-DIACETYL-2 4 6-TRIMETHYL-1 4-DIHYDR&
• Synonyms: 3 5-DIACETYL-2 4 6-TRIMETHYL-1 4-DIHYDR&;1,1'-(1,4-dihydro-2,4,6-trimethylpyridine-3,5-diyl)bisethan-1-one;3,5-Diacetyl-1,4-dihydro-2,4,6-trimethylpyridine;1-(5-acetyl-2,4,6-trimethyl-1,4-dihydropyridin-3-yl)ethanone;1-(5-ethanoyl-2,4,6-trimethyl-1,4-dihydropyridin-3-yl)ethanone;1-(5-acetyl-2,4,6-trimethyl-1,4-dihydro-3-pyridinyl)ethanone
• CAS NO: 1081-09-0
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.26888
• EINECS: 214-099-5
• Product Categories: C9 to C46;Heterocyclic Building Blocks;Pyridines;Building Blocks;C12;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 1081-09-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 154-159 °C(lit.)
• Boiling Point: 344.6oC at 760 mmHg
• Flash Point: 135oC
• Appearance: /
• Density: 1.018g/cm3
• PKA: 3.53±0.70(Predicted)
• CAS DataBase Reference: 3 5-DIACETYL-2 4 6-TRIMETHYL-1 4-DIHYDR&(CAS DataBase Reference)
• NIST Chemistry Reference: 3 5-DIACETYL-2 4 6-TRIMETHYL-1 4-DIHYDR&(1081-09-0)
• EPA Substance Registry System: 3 5-DIACETYL-2 4 6-TRIMETHYL-1 4-DIHYDR&(1081-09-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1081-09-0(Hazardous Substances Data)

Usage

General Description

3,5-Diacetyl-2,4,6-trimethyl-1,4-dihydropyridine is a chemical compound with the molecular formula C11H17NO2. It is a derivative of 1,4-dihydropyridine and is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical compound is a yellow to brown solid with a distinct odor and is commonly used as a flavoring agent in food products. It is also used as a reagent in organic chemistry reactions and as a precursor in the production of other important chemicals. Its chemical structure and properties make it useful for a variety of applications in the pharmaceutical and chemical industries.

Upstream product

• 108-05-4 vinyl acetate 
• 123-54-6 acetylacetone 
• 58052-80-5 2,4,6-Trimethyl-[1,3,5]triazinane; hydrate 
• 15181-39-2 3-ethylidene-pentane-2,4-dione 
• 75-07-0 acetaldehyde 

Downstream Products

• 1447968-00-4 (2E,2'E)-1,1'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(3-(4-bromophenyl)prop-2-en-1-one) 
• 1447967-99-8 (2E,2'E)-1,1'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(3-(4-chlorophenyl)prop-2-en-1-one) 
• 1447967-98-7 (2E,2'E)-1,1'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(3-(3-chlorophenyl)prop-2-en-1-one) 
• 1447967-97-6 (2E,2'E)-1,1'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(3-(4-nitrophenyl)prop-2-en-1-one) 
• 1447968-17-3 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-2,3-dihydro-[1,1'-biphenyl]-4(1H)-one) 
• 1447968-15-1 2,2'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-methyl-3-(p-tolyl)-1,3-oxazinane-4,6-dione) 
• 1447968-14-0 (N,N'E,N,N'E)-N,N'-((2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(ethan-1-yl-1-ylidene))bis(4-methylaniline) 
• 1447968-12-8 diethyl 5,5'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(2-acetyl-3-(4-chlorophenyl)-5-oxopentanoate) 
• 1447968-16-2 diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate) 
• 1447968-13-9 2,2'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4-(4-chlorophenyl)decahydroquinoline) 
• 1447968-11-7 2,2'-((2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(1-(4-chlorophenyl)-3-oxopropane-3,1-diyl))dicyclohexanone 
• 1447968-10-6 3,5-bis(5-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2,4,6-trimethyl-1,4-dihydropyridine 
• 1447968-09-3 3,5-bis(5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2,4,6-trimethyl-1,4-dihydropyridine 
• 1447968-08-2 3,3'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis-5-(4-bromophenyl)-4,5-di-hydroisoxazole 

Relevant articles and documents

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Synthesis and photochemistry of novel 3,5-diacetyl-1,4-dihydropyridines. II [1]

In continuation of previous work some novel 3,5-diacetyl-1,4- dihydropyridine derivatives were synthesized and their photochemical behavior was studied under oxygen and argon atmosphere. Oxidation of the dihydropyridine ring and formation of pyridine derivatives was the result of the reaction. The presence of oxygen affects not only on the rate of oxidation, but also the formation of some unidentified by-products was observed on irradiation under this atmosphere. Springer-Verlag 2004.

Ultrasound-mediated, uranyl nitrate hexahydrate-catalyzed synthesis of 1,4-dihydropyridines under mild conditions

Abstract Synthesis of 1,4-dihydropyridines by three-component condensation reaction of aldehyde, 1,3-dicarbonyl compounds, and ammonium acetate have been found to be efficiently catalyzed by uranyl nitrate hexahydrate [UO2(NO3)2 ·6H2O] at room temperature under ultrasound irradiation. This novel synthetic method offers the advantages of high yields, short reaction times, simplicity, and easy workup compared to the conventional methods reported in the literature.

Etidronic acid catalyzed synthesis of 1,4-dihydropyridines

One pot, three components cyclaconctensation reaction of various arylaldehydes. ethyl acetoacetate/acetyl acetone and ammonium acetate with etidronic acid as catalyst afforded the corresponding 1,4 -dihydropyridines in better yields under solvent free conditions.