107761-42-2

Basic information

• Product Name: beta-Amyloid (1-42) human
• Synonyms: Bate-Amyloid（1-42）human; (1-42) (human);AB42, betaamyloid peptide;Amyloid βH-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH;REF DUPL: H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH;Beta-Amyloid (1-42), sodium salt;Amyloid β-Peptide (1-42) (human)
• CAS NO: 107761-42-2
• Molecular Formula: C203H311N55O60S1
• Molecular Weight: 4514.04
• Product Categories: Signalling;Neuroscience;proteins;Peptide;Amyloid beta Protein Fragments;Amyloid β Protein FragmentsNeuropeptides;Alzheimers and Neurodegenerative Disease Research;Neurodegenerative Disease Peptides;β Amyloid Peptides;Amyloid beta-peptide and related
• Mol File: 107761-42-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• Solubility: Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO.
• CAS DataBase Reference: beta-Amyloid (1-42) human(CAS DataBase Reference)
• NIST Chemistry Reference: beta-Amyloid (1-42) human(107761-42-2)
• EPA Substance Registry System: beta-Amyloid (1-42) human(107761-42-2)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 107761-42-2(Hazardous Substances Data)

Usage

Description

Beta-Amyloid (1-42) human, also known as Aβ1-42, is a peptide fragment derived from the Amyloid β Protein, which is produced from the amyloid-β precursor protein (APP). This peptide consists of 42 amino acids and is one of the two C-terminal variants of the protein, with the other being the shorter Aβ1-40. The APP is located on human chromosome 21q21.3, and the chemical properties of Beta-Amyloid (1-42) human are solid.

Uses

Used in Pharmaceutical and Biomedical Research:
Beta-Amyloid (1-42) human is used as a research tool for studying various metabolic and regulatory functions, including the activation of kinases, regulation of cholesterol transport, and its role as a transcription factor. It is also used to investigate the function of Aβ peptides and their peptide fragments as regulators of inflammation.
Used in Alzheimer's Disease and Neurodegeneration Research:
Beta-Amyloid (1-42) human is used as a key molecule in the study of oxidative stress, metal binding, and mechanisms of protein cross-linking in the context of diseases such as Alzheimer's disease and neurodegeneration. This application helps researchers understand the role of Aβ peptides in the development and progression of these diseases and aids in the development of potential therapeutic strategies.
Used in Drug Development:
Beta-Amyloid (1-42) human is used as a target for drug development, as it plays a significant role in the pathogenesis of Alzheimer's disease. By studying the interactions of this peptide with various compounds, researchers can develop drugs that modulate its aggregation, toxicity, and clearance, potentially leading to novel treatments for Alzheimer's and other neurodegenerative disorders.

Biochem/physiol Actions

Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties.