107649-71-8Relevant articles and documents
Development of Asymmetric Transfer Hydrogenation with a Bifunctional Oxo-Tethered Ruthenium Catalyst in Flow for the Synthesis of a Ceramide (D-erythro-CER[NDS])
Touge, Taichiro,Kuwana, Masahiro,Komatsuki, Yasuhiro,Tanaka, Shigeru,Nara, Hideki,Matsumura, Kazuhiko,Sayo, Noboru,Kashibuchi, Yoshinobu,Saito, Takao
, p. 452 - 461 (2019)
The development of an efficient synthetic route for an optically active ceramide compound (d-erythro-CER[NDS]) is described. The route proceeds through asymmetric transfer hydrogenation in a pipes-in-series flow reactor with oxo-tethered ruthenium complex-catalyzed dynamic kinetic resolution. This synthesis was accomplished without any expensive reagents, and none of the intermediates required isolation. This resulted in a robust process that has been successfully run on a production scale.
A versatile route to syn- and anti-α-amino β-hydroxy esters from β-keto esters by dynamic kinetic resolution with Ru-SYNPHOS catalyst
Mordant, Celine,Duenkelmann, Pascal,Ratovelomanana-Vidal, Virginie,Genet, Jean-Pierre
, p. 3017 - 3026 (2007/10/03)
A general and practical synthesis of both syn- and anti-α-amino β-hydroxy esters with high levels of selectivity by the use of Ru-SYNPHOS catalysts is reported. The key transformations include asymmetric hydrogenations of α-N-substituted β-keto esters pro
