106636-74-2

Basic information

• Product Name: 1α-bromo-desoxypodophyllotoxin
• Synonyms: 1α-bromo-desoxypodophyllotoxin
• CAS NO: 106636-74-2
• Molecular Weight: 477.309
• Mol File: 106636-74-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1α-bromo-desoxypodophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 1α-bromo-desoxypodophyllotoxin(106636-74-2)
• EPA Substance Registry System: 1α-bromo-desoxypodophyllotoxin(106636-74-2)

Safety Data

• Hazardous Substances Data: 106636-74-2(Hazardous Substances Data)

Upstream product

• 1014671-34-1 (-)-podophyllotoxin 
• 477-51-0 deoxypodophyllotoxin 
• 518-28-5 podofilox 

Downstream Products

• 117507-84-3 (5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 610316-83-1 4β-1''-[4''-(benzoyl)-2''-nitroanilino]-4-desoxypodophyllotoxin 
• 610316-81-9 4β-1''-[3''-(benzoyl)anilino]-4-desoxypodophyllotoxin 
• 1014671-34-1 (-)-podophyllotoxin 
• 199464-34-1 C₂₂H₂₀O₇ 
• 477-48-5 podophyllotoxone 
• 4375-06-8 epipicropodophyllotoxin 
• 155252-36-1 4α-acetamido-4-deoxypodophyllotoxin 
• 155325-20-5 4α-azido-4-deoxypicropodophyllotoxin 
• 155325-18-1 4β-amino-4-deoxy-epipodophyllotoxin 
• 155325-21-6 4α-amino-4-deoxypicropodophyllotoxin 
• 127882-73-9 4'-O-demethyl-4β-(4''-nitroanilino)-4-desoxypodophyllotoxin 
• 127882-54-6 4'-O-demethyl-4β-anilino-4-desoxypodophyllotoxin 

Relevant articles and documents

An efficient method for 4β-anilino-4'-demethylepipodophyllotoxins: Synthesis of NPF and W-68

4β-Substituted podophyllotoxin congeners have been obtained with significant stereoselectivity and improved yields by employing Bu4N+I in the displacement reaction of the 4-bromoepipodophyllotoxin. The DNA topoisomerase II inhibitors, NPF and W-68 have been prepared in good yields by this method.

CONVERSION

The present invention provides a process for the in vitro conversion of deoxypodophyllotoxin to podophyllotoxin. In vitro conversion of deoxypodophyllotoxin to podophyllotoxin is carried out by direct oxidation at the 7-position, full oxidation at the 7-p

Thermal chemistry of podophyllotoxin in ethanol and a comparison of the cytostatic activity of the thermolysis products

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