106612-94-6

Basic information

• Product Name: H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH
• Synonyms: Insulinotropin (human);Peptide GLP-1 (human glucose-lowering peptide-1);Glp-I (7-37);Glucagon like peptide I (7-37);Glucagon-related peptide (oncorhynchus kisutch), 3-L-glutamic acid-6-L-phenylalanine-9-L-aspartic acid-12-L-serine-15-L-glutamic acid-16-glycine-21-L-isoleucine-24-L-alanine-27-L-valine-28-L-lysine-31-glycine-;Tglp-1;GLP-1, 7-37;Preproglucagon 78-108
• CAS NO: 106612-94-6
• Molecular Formula: C151H228N40O47
• Molecular Weight: 3355.67
• Product Categories: peptide;peptides pharm
• Mol File: 106612-94-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• Water Solubility: Soluble in water at 2mg/ml
• CAS DataBase Reference: H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH(106612-94-6)
• EPA Substance Registry System: H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH(106612-94-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 106612-94-6(Hazardous Substances Data)

Usage

Description

H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH is a peptide sequence that represents the structure of Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)). It is an amino-truncated form of GLP-1, a hormone that plays a significant role in glucose homeostasis and insulin secretion.

Uses

Used in Pharmaceutical Industry:
H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH is used as a positive control for insulin secretion of pancreatic islets. It helps in understanding the insulin response in horse islets and can be used in combination with mesenchymal stem cells (MSCs) to test its protective effects in myocardial infarction.
Used in Research and Development:
H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH is used as a research tool to study the effects of GLP-1 on glucose homeostasis and insulin secretion. It can be utilized in the development of new drugs and therapies for diabetes and other related conditions.
Used in Diagnostic Applications:
H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH can be used in diagnostic tests to evaluate the function of pancreatic islets and the effectiveness of insulin secretion in response to various stimuli.

Biochem/physiol Actions

Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)) interacts with the GLP-1 receptor (GLP-1r). It mediates insulin release by stimulating the cyclic AMP accumulation in islet cells GLP-l(7-37) is a potential therapeutic agent due to its insulin-secretagogue functionality.