106584-51-4

Basic information

• Product Name: 3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI)
• Synonyms: 3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI);Methyl 6-Methylpyridazine-3-carboxylate;6-Methyl-3-pyridazinecarboxylic acid methyl ester
• CAS NO: 106584-51-4
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15
• Product Categories: CARBOXYLICESTER;GLYCINESCAFFOLD
• Mol File: 106584-51-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI)(106584-51-4)
• EPA Substance Registry System: 3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI)(106584-51-4)

Safety Data

• Hazardous Substances Data: 106584-51-4(Hazardous Substances Data)

Usage

General Description

3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI) is a chemical compound with the molecular formula C8H8N2O2. It is also known as 6-methylnicotinic acid methyl ester. 3-Pyridazinecarboxylicacid,6-methyl-,methylester(9CI) is a methyl ester derivative of 3-pyridazinecarboxylic acid, and it is commonly used in organic synthesis and pharmaceutical research. It has potential applications in the development of new drugs and agrochemicals due to its unique chemical properties. However, its specific uses and potential health effects are not well-documented, and further research and testing may be necessary to determine its safety and efficacy.

Upstream product

• 186581-53-3 diazomethane 
• 78490-07-0 2-Benzoyl-6-methyl-2,3-dihydro-pyridazine-3-carbonitrile 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 157200-06-1 Trifluoromethanesulfonic acid 6-methylpyridazine-3-yl ester 
• 1121-79-5 3-chloro-6-methylpyridazine 
• 13327-27-0 6-Methylpyridazin-3(2H)-on 

Relevant articles and documents

Continuous-Flow Pd-Catalyzed Carbonylation of Aryl Chlorides with Carbon Monoxide at Elevated Temperature and Pressure

The development of a continuous-flow protocol for a palladium-catalyzed methoxycarbonylation of (hetero)aryl chlorides using carbon monoxide gas and methanol is described. (Hetero)aryl chlorides are the least expensive of the aryl halides, but are underutilized in carbonylation reactions due to their very poor reactivity. The described protocol exploits intensified conditions at elevated temperature and pressure, which are readily accessed within a continuous-flow environment, to provide moderate to excellent product yields (11 examples) in a short 16 min residence time. The continuous-flow protocol enables the safe and potentially scalable carbonylation of aryl chlorides using CO gas.

Pyridazines. XXV . Formation of 2-Benzoyl-2,5-dihydro-3-pyridazinecarbonitrile Derivatives in the Reissert Reaction of Pyridazines

Pyridazines 1a,b on treatment with potassium cyanide/benzoyl chloride in a mixed solvent system gave 2-benzoyl-2,5-dihydro-3-pyridazinecarbonitriles 3a,b together with products resulting from attack of one mole of cyanide ion and three moles of benzoyl chloride (5a,b).The structures of these novel compounds are proved.A plausible reaction mechanism is proposed, involving rearrangement of initially formed 2a,b into 3a,b.Furthermore, the synthesis of the pyridazine Reissert compound 2a is reported.