106375-28-4

Basic information

• Product Name: OMEGA-CONOTOXIN GVIA
• Synonyms: CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2;CKS(HYP)GSSCS(HYP)TSYNCCRSCN(HYP)TKRCY-NH2;H-CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2;H-CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2 (DISULFIDE BRIDGES: 1-16, 8-19, 15-26);OMEGA-CONOTOXIN GVIA, CONUS GEOGRAPHUS;OMEGA-CONOTOXIN GVIA ISOMER;OMEGA-CGTX GVIA;OMEGA-CONOTOXIN GVIA
• CAS NO: 106375-28-4
• Molecular Formula: C120H182N38O43S6
• Molecular Weight: 3037.35
• Product Categories: Calcium Channel Modulators;Ion Channel Modulating Peptides;Peptide ToxinsCell Signaling and Neuroscience;Peptide ToxinsPeptides for Cell Biology;Snail;Toxins and Venoms;Voltage-gated Ion Channels;Calcium channel;Ion Channels;peptide
• Mol File: 106375-28-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.71
• Storage Temp.: −20°C
• CAS DataBase Reference: OMEGA-CONOTOXIN GVIA(CAS DataBase Reference)
• NIST Chemistry Reference: OMEGA-CONOTOXIN GVIA(106375-28-4)
• EPA Substance Registry System: OMEGA-CONOTOXIN GVIA(106375-28-4)

Safety Data

• RIDADR: 3172
• WGK Germany: 3
• RTECS: GL2665050
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 106375-28-4(Hazardous Substances Data)

Usage

Description

OMEGA-CONOTOXIN GVIA, also known as ω-Conotoxin GVIA, is a peptide toxin derived from the venom of the Conus catus, a species of cone snail. It is a potent and selective N-type calcium channel (CaV2.2) blocker, which has been extensively studied for its potential therapeutic applications. The peptide's unique structure and mechanism of action make it a valuable tool in neuroscience and pharmacology research.

Uses

Used in Neuroscience Research:
OMEGA-CONOTOXIN GVIA is used as a research tool for studying the function and role of N-type calcium channels in various neuronal processes. Its ability to selectively block these channels allows researchers to investigate their involvement in synaptic transmission, pain signaling, and other neurological functions.
Used in Pain Management:
OMEGA-CONOTOXIN GVIA is used as an analgesic agent, particularly for the management of chronic and neuropathic pain. By blocking N-type calcium channels, it can reduce the release of neurotransmitters involved in pain signaling, providing relief from pain without the risk of addiction associated with traditional opioids.
Used in Drug Development:
OMEGA-CONOTOXIN GVIA serves as a lead compound in the development of new drugs targeting N-type calcium channels for various therapeutic applications. Its selective action on these channels makes it an attractive starting point for designing more potent and specific drugs with fewer side effects.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, OMEGA-CONOTOXIN GVIA is used as a reference compound for the development of new drugs targeting N-type calcium channels. Its well-characterized properties and mechanism of action provide a valuable benchmark for assessing the efficacy and selectivity of newly developed compounds.
Used in Clinical Trials:
OMEGA-CONOTOXIN GVIA is used as an investigational drug in clinical trials for the treatment of various pain conditions, including chronic and neuropathic pain. These trials aim to evaluate its safety, efficacy, and potential side effects in human subjects, with the ultimate goal of obtaining regulatory approval for its use in pain management.

Biochem/physiol Actions

ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities.