1061354-48-0 Usage
Chemical class
Pyridoindole alkaloids
Type of compound
Monohydrochloride salt
Common uses
Research as a potent and selective dopamine receptor agonist
Potential pharmacological effects
Modulating neurotransmitter levels, influencing behavior
Value in research
Understanding neurological pathways, potential therapeutic applications in conditions related to dopamine dysregulation (e.g. Parkinson's disease, schizophrenia)
Specific molecular structure
2,8-dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole monohydrochloride
Check Digit Verification of cas no
The CAS Registry Mumber 1061354-48-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,1,3,5 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1061354-48:
(9*1)+(8*0)+(7*6)+(6*1)+(5*3)+(4*5)+(3*4)+(2*4)+(1*8)=120
120 % 10 = 0
So 1061354-48-0 is a valid CAS Registry Number.
1061354-48-0Relevant articles and documents
Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles
Ivachtchenko, Alexandre V.,Frolov, Eugen B.,Mitkin, Oleg D.,Tkachenko, Sergei E.,Okun, Ilya M.,Khvat, Alex V.
experimental part, p. 78 - 82 (2010/04/02)
Syntheses, biological evaluation, and structure-activity relationships for a series of novel 5-styryl and 5-phenethyl analogs of dimebolin are disclosed. The novel derivatives and dimebolin share a broad spectrum of activities against therapeutically relevant targets. Among all synthesized derivatives, 2,8-dimethyl-5-[(Z)-2-phenylvinyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]in dole and its 5-phenethyl analog are the most potent blockers of 5-HT7, 5-HT6, 5-HT2C, Adrenergic α2 and H1 receptors. The general affinity rank order towards the studied receptors was Z-3(2) > 4(2) ≥ 4(3) ? dimebolin, all of them having highest affinities to 5-HT7 receptors.
