105827-74-5

Basic information

• Product Name: 5-(BROMOMETHYL)-2-FLUOROPYRIDINE
• Synonyms: 5-(BROMOMETHYL)-2-FLUOROPYRIDINE;5-(BroMoMethyl)-2-fluorop...
• CAS NO: 105827-74-5
• Molecular Formula: C₆H₅BrFN
• Molecular Weight: 190.02
• Mol File: 105827-74-5.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 5-(BROMOMETHYL)-2-FLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(BROMOMETHYL)-2-FLUOROPYRIDINE(105827-74-5)
• EPA Substance Registry System: 5-(BROMOMETHYL)-2-FLUOROPYRIDINE(105827-74-5)

Safety Data

• Hazardous Substances Data: 105827-74-5(Hazardous Substances Data)

Usage

Description

5-(BROMOMETHYL)-2-FLUOROPYRIDINE is an organic compound characterized by its unique molecular structure, which features a fluorine atom at the 2nd position and a bromomethyl group at the 5th position of the pyridine ring. 5-(BROMOMETHYL)-2-FLUOROPYRIDINE is known for its reactivity and potential applications in various chemical and pharmaceutical processes.

Uses

Used in Pharmaceutical Industry:
5-(BROMOMETHYL)-2-FLUOROPYRIDINE is used as a reagent for the preparation of N-Benzylisatinsulfonamides, which are potent inhibitors of caspase-3. Caspase-3 is a crucial enzyme involved in the execution phase of apoptosis, or programmed cell death. By inhibiting caspase-3, N-Benzylisatinsulfonamides can potentially be used in the development of treatments for various diseases and conditions where apoptosis plays a significant role, such as cancer, neurodegenerative disorders, and autoimmune diseases.

Upstream product

• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 2369-19-9 2-fluoro-5-methylpyridine 

Downstream Products

• 1253569-19-5 tert-butyl 4-((6-(6-methoxypyridin-3-ylamino)-5-(4-methyl-6-(methylthio)-1,3,5-triazin-2-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate 
• 1298135-05-3 N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(piperazin-1-ylmethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine 
• 1253569-13-9 tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-fluoropyridin-3-yl)methyl)piperazine-1-carboxylate 
• 1253569-01-5 5-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-2-fluoropyridin-3-ylboronic acid 
• 915408-48-9 N-(7-((6-fluoropyridin-3-yl)methyl)-9-(4-methoxybenzyloxy)-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl)-N-methylmethanesulfonamide 
• 205744-17-8 2-fluoropyridin-5-ylmethylamine 

Relevant articles and documents

Synthesis and herbicidal activity of 2-cyano-3-(2-fluoro-5-pyridyl) methylaminoacrylates

A series of 2-cyano-3-(2-fluoro-5-pyridyl)methylaminoacrylates were synthesized as herbicidal inhibitors of photosystem II (PSII) electron transport. 2-Fluoro-5-pyridinemethylamine was prepared from 2-amino-5- methylpyridine, subsequent reaction with 2-cyano-3,3-dimethylthioacrylates or 2-cyano-3-methoxyacrylates to yield these title compounds. All of these compounds were confirmed by 1H NMR, IR, mass spectrum and elemental analyses. Their herbicidal activities were evaluated. All of the title compounds showed excellent herbicidal activities to amaranth pigweed and rape in post-emergence treatment. At the rate of 150 g/ha, one compound exhibited similar activity to Cl-analogue. The replacement of chlorine by fluorine group showed the same herbicidal activity.

MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound formula (I).

Mesoionic pyrido[1,2-a]pyrimidinones: Discovery of triflumezopyrim as a potent hopper insecticide1

A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program which led to the discovery of triflumezopyrim as a highly potent insecticide controlling various hopper species. Our efforts in discovery, synthesis, structure-activity relationship elucidation, and biological activity evaluation are also presented.