104974-45-0

Basic information

• Product Name: (s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid
• Synonyms: (s)-2-amino-1,2,3,4-tetrahydro-2-naphthoic acid;(s)-2-aminotetralin-2-carboxylic acid;2-Naphthalenecarboxylicacid,2-amino-1,2,3,4-tetrahydro-,(2S)-(9CI);(S)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid, (S)-2-Aminotetralin-2-carboxylic acid
• CAS NO: 104974-45-0
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Product Categories: AMINOACID
• Mol File: 104974-45-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid(104974-45-0)
• EPA Substance Registry System: (s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid(104974-45-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 104974-45-0(Hazardous Substances Data)

Usage

Description

(s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid is a complex chemical compound that serves as an amino acid derivative. It features a naphthalene ring and a carboxylic acid group, which contribute to its unique properties. This chiral molecule, with its (s) stereochemistry, holds significant potential in medicinal chemistry and drug development due to its promising biological activities. (s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid's structure and properties make it a valuable candidate for research in drug design and development, with its pharmaceutical relevance attracting further study and exploration.

Uses

Used in Pharmaceutical Industry:
(s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid is used as a key component in drug design for its potential biological activities. (s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid's unique structure allows it to interact with various biological targets, making it a promising candidate for the development of new pharmaceuticals.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid is used as a starting material or a building block for the synthesis of novel compounds with potential therapeutic applications. Its chiral nature and complex structure provide a foundation for creating diverse molecules with specific biological functions.
Used in Drug Development:
(s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid is utilized in drug development as a template for creating new drugs with improved efficacy and selectivity. Its unique properties and potential interactions with biological targets make it an attractive compound for the development of targeted therapies and other advanced treatment options.
Used in Chiral Chemistry:
The (s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid's chirality makes it an important compound in chiral chemistry, where the study of the physical and chemical properties of chiral molecules is crucial. It can be used to explore the effects of stereochemistry on biological activity and to develop enantioselective synthetic methods for producing chiral drugs.
Used in Chemical Synthesis:
As a complex molecule with a naphthalene ring and carboxylic acid group, (s)-2-amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid is used in chemical synthesis to create a variety of derivatives with different properties and applications. These derivatives can be further explored for their potential uses in various industries, including pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 52094-70-9 7,8-benzo-1,3-diazasprio[4.5]decane-2,4-dione 
• 6331-63-1 2-amino-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid 
• 74444-82-9 diaza-2,4 dioxo-3,5 chloro 6'spiro (cyclopentane-1) 
• 17556-18-2 6-chloro-3,4-dihydro-1H-naphthalen-2-one 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 162098-74-0 2-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile 
• 144800-66-8 2-amino-2-(aminocarbonyl)-1,2,3,4-tetrahydronaphthalene 
• 74444-73-8 acide amino-2 chloro-6 tetrahydro-1,2,3,4 naphtoique-2 

Downstream Products

• 104974-44-9 (R)-2-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 
• 1567898-41-2 2-(4-fluorobenzamido)-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 
• 117099-27-1 3,4-dihydro-1H-spiro[naphthalene-2,4'-oxazolidine]-2',5'-dione 
• 144732-19-4 (R)-2-benzamido-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 
• 144732-06-9 (S)-methyl 2-benzamido-1,2,3,4-tetrahydronaphthalene-2-carboxylate 
• 144732-05-8 (R)-methyl 2-benzamido-1,2,3,4-tetrahydronaphthalene-2-carboxylate 
• 144646-27-5 methyl 2-benzamido-1,2,3,4-tetrahydronaphthalene-2-carboxylate 
• 144731-96-4 N^2.2-<(S)-2-benzamido-1,2,3,4-tetrahydronaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N^1.3,N^1.3-(tetramethylene)amide 
• 144646-42-4 N^2.2-<(R)-2-benzamido-1,2,3,4-tetrahydronaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N^1.3,N^1.3-(tetramethylene)amide 
• 144646-53-7 (R)-2-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid hydrochloride 
• 91733-79-8 <<(2-benzyloxycarbamido)-2-tetralyl>carbonyl>glycylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 104974-44-9 (S)-2-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 
• 108651-08-7 2-thioxo-3',4'-dihydro-1'H-spiro[imidazolidine-4,2'-naphthalen]-5-one 

Relevant articles and documents

Candida antarctica Lipase B in a chemoenzymatic route to cyclic α-quaternary α-amino acid enantiomers

Kinetic resolution of three cyclic quaternary ethyl 1-amino-2,3-dihydro-1H- indene-1-carboxylates and both 1- and 2-amino-1,2,3,4-tetrahydronaphthalene analogues have been studied. Interesterification with butyl butanoate and Candida antarctica lipase B accomplished the task. The enantiomers of all 1-amino analogues reacted with excellent enantioselectivity (enantiomeric ratio er greater than 200), whereas the 2-amino analogue was not enantioselective (er = 4). Amino acid enantiomers were finally obtained as their respective hydrochlorides with almost maximum theoretical yields. For the first time, a lipase enzyme was effectively used in the kinetic resolution of cyclic α-quaternary α-amino esters. Copyright

TETRALINE DERIVATIVES AS GHRELIN RECEPTOR MODULATORS

The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.

Conformationally constrained deltorphin analogs with 2-aminotetralin-2- carboxylic acid in position 3

Two approaches to the design of very active and highly selective δ opioid peptides were used to obtain new deltorphin analogs with altered hydrophobic and stereoelectronic properties. Deltorphin I and II analogs were synthesized involving the substitution of Ile instead of Val at positions 5 and 6 in the address domain and 2-aminotetralin-2-carboxylic acid (Atc) instead of Phe in the message domain. The peptides were agonists in the subnanomolar range in the MVD assay and in the micromolar or higher range in the GPI assay, showing a very high selectivity for δ receptors. A very similar trend could be observed in radioreceptor binding assays in which selective tritiated opioid ligands were used. (R)- and (S)-Atc-deltorphins exhibited similar K(i) values in the binding assay, with almost complete loss of the stereospecificity of the binding. Conformational studies provided evidence for little disturbance of the backbone conformational equilibrium when Phe3 is replaced by (S)- or (R)-Atc. The use of the Atc constraint gives additional evidence that, during its interaction with the δ receptor, the side chain of residue 3 adopts the trans conformation at χ1.