10475-15-7

Basic information

• Product Name: 2-hydroxy-3-(3-oxo-1,3-diphenylpropyl)-4H-chromen-4-one
• CAS NO: 10475-15-7
• Molecular Formula: C₂₄H₁₈O₄
• Molecular Weight: 370.3973
• Mol File: 10475-15-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 573.1°C at 760 mmHg
• Flash Point: 201.7°C
• Density: 1.315g/cm³
• Vapor Pressure: 5.63E-14mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 2-hydroxy-3-(3-oxo-1,3-diphenylpropyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-(3-oxo-1,3-diphenylpropyl)-4H-chromen-4-one(10475-15-7)
• EPA Substance Registry System: 2-hydroxy-3-(3-oxo-1,3-diphenylpropyl)-4H-chromen-4-one(10475-15-7)

Safety Data

• Hazardous Substances Data: 10475-15-7(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 94-41-7 benzalacetophenone 

Downstream Products

• 1342296-37-0 2,4-diphenyl-4H-thiopyrano[3,2-c]chromen-5-one 
• 92824-16-3 4-hydroxy-3-(1,3-diphenyl-3-butenyl)-2H-1-benzopyran-2-one 
• 90361-87-8 trans-3,4-dihydro-2-hydroxymethyl-2,4-diphenyl-2H,5H-pyrano<3,2-c><1>benzopyran-5-one 
• 90361-89-0 (2R,4S)-2-Hydroxymethyl-2,4-diphenyl-3,4-dihydro-2H-pyrano[2,3-b]chromen-5-one 

Relevant articles and documents

Reaction between Chalcones, 1,3-Dicarbonyl Compounds, and Elemental Sulfur: A One-Pot Three-Component Synthesis of Substituted Thiophenes

A simple and atom-economic synthesis of highly substituted thiophenes is demonstrated. Heating a solution of a chalcone and a linear/cyclic 1,3-dicarbonyl compound with elemental sulfur in CH 3 CN in the presence of NEt 3 at 80 °C af

Hypoiodite-catalysed oxidative cyclisation of Michael adducts of chalcones with 1,3-dicarbonyl compounds: A facile and versatile approach to substituted furans and cyclopropanes

Through hypoiodite catalysis, oxidative cyclisation of Michael adducts of chalcones with 1,3-dicarbonyl compounds for divergent synthesis of either furans or cyclopropanes is developed. The selective synthesis of major products is achieved depending on the use of different reaction conditions or substrates.

Synthesis and pharmacological investigations of some 4-hydroxycoumarin derivatives

The synthesis of ten coumarin derivatives of 4-hydroxycoumarin and various unsaturated ketones and aldehydes is described. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, and mass-spectral data. Acute toxicity studies of the compounds were performed on mice by oral and intraperitoneal administration. A comparative pharmacological study of the in vivo anticoagulant effects of the derivatives with respect to warfarin, showed that the compounds have anticoagulant activity. Compounds 4-hydroxy-3-[1-phenyl-2-(4′-chlorobenzoyl)-ethyl]-2H-1-benzopyran-2-one 2b, 4-hydroxy-3-[1-(4-fluorophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one 3a, and 3,3′-p-bromobenzylidene-bis-(4-hydroxy-2H-1-benzopyran-2-one) 4 b showed slight acute toxicity and a greater anticoagulant effect than warfarin.