10472-88-5

Basic information

• Product Name: 2-BROMO-4-FLUORO-6-NITROANILINE
• Synonyms: 2-BROMO-4-FLUORO-6-NITROANILINE;2-Bromo-4-fluoro-6-nitroaniline 98%;2-Bromo-4-fluoro-6-nitroaniline98%;2-Amino-3-bromo-5-fluoronitrobenzene;BenzenaMine, 2-broMo-4-fluoro-6-nitro-;2-bromo-4-fluoro-6-nitrobenzenamine
• CAS NO: 10472-88-5
• Molecular Formula: C₆H₄BrFN₂O₂
• Molecular Weight: 235.01
• EINECS: 1533716-785-6
• Product Categories: Amines;Phenyls & Phenyl-Het
• Mol File: 10472-88-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 70-72°C
• Boiling Point: 313.9 °C at 760 mmHg
• Flash Point: 143.6 °C
• Appearance: Orange/Powder
• Density: 1.896 g/cm³
• Vapor Pressure: 0.000483mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-BROMO-4-FLUORO-6-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-FLUORO-6-NITROANILINE(10472-88-5)
• EPA Substance Registry System: 2-BROMO-4-FLUORO-6-NITROANILINE(10472-88-5)

Safety Data

• Hazard Codes: T
• HazardClass: 6.1
• Hazardous Substances Data: 10472-88-5(Hazardous Substances Data)

Usage

Description

2-BROMO-4-FLUORO-6-NITROANILINE is an organic compound characterized by its off-white powder form. It is a derivative of aniline, featuring a bromo, fluoro, and nitro functional groups at the 2nd, 4th, and 6th positions respectively. 2-BROMO-4-FLUORO-6-NITROANILINE is known for its unique chemical properties and is utilized in various applications across different industries.

Uses

Used in Pharmaceutical Industry:
2-BROMO-4-FLUORO-6-NITROANILINE is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique chemical structure allows it to serve as a building block in the development of new pharmaceutical compounds, contributing to the advancement of medical treatments.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-BROMO-4-FLUORO-6-NITROANILINE is employed as a key intermediate in the production of a range of chemical products. Its distinct functional groups enable it to participate in various chemical reactions, facilitating the creation of new compounds with diverse applications.
Used in Research and Development:
2-BROMO-4-FLUORO-6-NITROANILINE is also utilized in research and development settings, where it is studied for its potential applications in various scientific fields. Its unique properties make it an interesting subject for exploration, and it may hold the key to unlocking new discoveries and innovations in the future.

InChI:InChI=1/C6H4BrFN2O2/c7-4-1-3(8)2-5(6(4)9)10(11)12/h1-2H,9H2

Upstream product

• 364-78-3 2-nitro-4-fluoroaniline 

Downstream Products

• 115440-10-3 3-bromo-5-fluoro-1,2-phenylenediamine 
• 912444-99-6 2-amino-5-fluoro-3-nitrobenzonitrile 
• 7087-65-2 1-bromo-3-fluoro-5-nitrobenzene 
• 934162-32-0 2,3-diamino-5-fluorobenzamide 
• 936551-84-7 2-amino-5-fluoro-3-nitrobenzamide 
• 1245642-98-1 4-bromo-6-fluoro-1H-benzo[d]imidazole 
• 1312923-89-9 3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorobenzene 
• 144580-08-5 2-Iodo-3-bromo-5-fluoroaniline 
• 144580-17-6 1-iodo-2-nitro-4-fluoro-6-bromobenzene 

Relevant articles and documents

Directed biosynthesis of 5'-fluoropactamycin in Streptomyces pactum

A new pactamycin analogue, 5'-fluoropactamycin, was prepared by directed biosynthesis. Supplementation of the fermentation medium of Streptomyces pactum, var. pactum with 3-amino-5-fluorobenzoic acid, an analogue of 3-aminobenzoic acid, an advanced precursor in pactamycin biosynthesis, resulted in co-production of pactamycin and the new pactamycin analogue. A similar feeding experiment with 3-amino-5-methylbenzoic acid did not result in formation of the corresponding methylated pactamycin analogue, but only in inhibition of pactamycin production. Comparison of antimicrobial and cytotoxic activities of pactamycin and 5'-fluoropactamycin showed no significant differences.

Fluorine atom substituted benzo heterocycle based conjugated molecule material as well as preparation method and application thereof

The invention discloses a fluorine atom substituted benzo heterocycle based conjugated molecule material as well as a preparation method and application thereof. The conjugated molecule material is ofan acceptor-donor-acceptor type structure, wherein an a

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted- phenyl series

We report the synthesis of four series of 3,5-disubstituted-phenyl ligands targeting the metabotropic glutamate receptor subtype 5: (2-methylthiazol-4-yl) ethynyl (1a-j,), (6-methylpyridin-2-yl)ethynyl (2a-j), (5-methylpyridin-2-yl) ethynyl (3a-j,), and (pyridin-2-yl)ethynyl (4a-j,). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro assay. All compounds were found to be full antagonists and exhibited low nanomolar to subnanomolar activity.