104680-25-3

Basic information

• Product Name: 3,4-Diethyl 2-aMinothiophene-3,4-dicarboxylate
• Synonyms: 3,4-Diethyl 2-aMinothiophene-3,4-dicarboxylate;Diethyl 2-amino-3,4-thiophenedicarboxylate;nchembio744-comp27;2-Amino-3,4-thiophenedicarboxylic acid 3,4-diethyl ester;2-Amino-3,4-thiophenedicarboxylic acid diethyl ester;2-Amino-thiophen-3,4-dicarboxylic acid diethyl ester;Diethyl 2-amino-thiophen-3,4-dicarboxylate
• CAS NO: 104680-25-3
• Molecular Formula: C10H13NO4S
• Molecular Weight: 243.27952
• Mol File: 104680-25-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 341.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.280±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: -0.98±0.10(Predicted)
• CAS DataBase Reference: 3,4-Diethyl 2-aMinothiophene-3,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Diethyl 2-aMinothiophene-3,4-dicarboxylate(104680-25-3)
• EPA Substance Registry System: 3,4-Diethyl 2-aMinothiophene-3,4-dicarboxylate(104680-25-3)

Safety Data

• Hazardous Substances Data: 104680-25-3(Hazardous Substances Data)

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 80691-81-2 2,5-diamino-thiophene-3,4-dicarboxylic acid diethyl ester 
• 104680-24-2 diethyl 2-hydrazinothiophene-3,4-dicarboxylate hydrochloride 

Relevant articles and documents

Preparation method of 2-aminothiophene-3,4-dicarboxylic acid derivative

The invention relates to a preparation method of a 2-aminothiophene-3,4-dicarboxylic acid derivative, and mainly solves the technical problem that the purification of the existing preparation method needs column chromatography and cannot be produced on a large scale. The preparation method comprises (1) reacting pyruvate, cyanoacetate and sulfur powder in the presence of an alkali and a solvent toobtain a reaction solution; (2) diluting the obtained reaction solution with ethyl acetate, washing with a citric acid aqueous solution, a sodium chloride aqueous solution and water in sequence to obtain a crude 2-aminothiophene-3,4-dicarboxylic acid derivative solution; (3) cooling the obtained crude 2-aminothiophene-3,4-dicarboxylic acid derivative solution to 0 to -20DEG C, and introducing a dry hydrogen chloride gas until all solids are separated out; (4) using 0 to -20DEG C ethyl acetate to wash filtered filter cake for once, and adjusting the pH to 7-8 with saturated sodium bicarbonate;(5) performing liquid separating, collecting an organic phase, washing the organic phase with an aqueous solution to obtain a pure 2-aminothiophene-3,4-dicarboxylic acid derivative solution; and (6)removing the ethyl acetate to obtain the pure 2-aminothiophene-3,4-dicarboxylic acid derivative.

THERAPEUTICALLY ACTIVE FUSED PYRIMIDINE DERIVATIVES

A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.