104330-60-1

Basic information

• Product Name: Propanoic acid, 3-[(4-fluorophenyl)amino]-3-oxo-, ethyl ester
• CAS NO: 104330-60-1
• Molecular Formula: C11H12FNO3
• Molecular Weight: 225.22
• Mol File: 104330-60-1.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 3-[(4-fluorophenyl)amino]-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-[(4-fluorophenyl)amino]-3-oxo-, ethyl ester(104330-60-1)
• EPA Substance Registry System: Propanoic acid, 3-[(4-fluorophenyl)amino]-3-oxo-, ethyl ester(104330-60-1)

Safety Data

• Hazardous Substances Data: 104330-60-1(Hazardous Substances Data)

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 371-40-4 4-fluoroaniline 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 55552-69-7 2-ethylmalonyl dichloride 
• 105-53-3 diethyl malonate 

Downstream Products

• 1474049-67-6 N¹-(4-fluorophenyl)-N³-(2-oxoindolin-6-yl)malonamide 
• 1474049-68-7 (Z)-N¹-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N³-(4-fluorophenyl)malonamide 
• 888721-65-1 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid 
• 1195782-42-3 5-methyl-2-oxo-1-(4-fluorophenyl)-1,2-dihydropyridine-3-carboxylic acid 
• 1195782-41-2 ethyl 5-methyl-2-oxo-1-(4-fluorophenyl)-1,2-dihydropyridine-3-carboxylate 
• 849217-68-1 cabozantinib 
• 1577180-07-4 N-(4-((6-bromo-1-methyl-1H-indazol-5-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1206801-36-6 tert-butyl 4-(5-(2-fluoro-4-(1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)-1-methyl-1H-indazol-6-yl)-1H-pyrazole-1-carboxylate 
• 1371609-90-3 ethyl 1-(4-fluorophenyl)-2-oxo-1,2-dihydro-1,7-naphthyridine-3-carboxylate 
• 1371609-89-0 2-[1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-[1,7]naphthyridine-3-carbonyl]-cyclohexane-1,3-dione 
• 1371609-91-4 1-(4-fluorophenyl)-2-oxo-1,2-dihydro-1,7-naphthyridine-3-carboxylic acid 
• 82607-62-3 malon-4-bromo-2-methyl anilic acid 
• 95262-10-5 3-((4-fluorophenyl)amino)-3-oxopropanoic acid 

Relevant articles and documents

MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF

The present invention relates to multi-substituted pyridone derivatives and therapeutic use thereof. In particular, the present invention relates to a compound of formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, as well as use thereof as a tyrosine kinase inhibitor, in particular, use thereof in treating a disease associated with tyrosine kinase activity. Each substituent in the formula (I) is defined as in the specification.

TRK INHIBITOR AS ANTI-CANCER DRUG

The present disclosure relates to a group of tropomyosin receptor kinase inhibitors comprising an amido-phenoxy-indazole structure fragment. These compounds show potent inhibitory effects on various oncogenic kinases, especially TRK, and thus can be used

THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Since a thienopyridine derivative compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof of the present invention has an excellent effect of inhibiting protein kinase activity, a pharmaceutical composition comprising the same can be usefully used for preventing or treating diseases related to protein kinase activity.COPYRIGHT KIPO 2020