1039307-95-3

Basic information

• Product Name: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid
• Synonyms: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid
• CAS NO: 1039307-95-3
• Molecular Weight: 283.37
• EINECS: -0
• Mol File: 1039307-95-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid(1039307-95-3)
• EPA Substance Registry System: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid(1039307-95-3)

Safety Data

• Hazardous Substances Data: 1039307-95-3(Hazardous Substances Data)

Usage

Description

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid is a chiral amino acid derivative with a molecular formula of C18H21NO2. It is an organic compound with two stereocenters and a biphenyl group attached to the α-amino group. This synthetic derivative is not a naturally occurring amino acid but has potential applications in pharmaceutical research and development. Its structural and stereochemical features make it an interesting target for further investigation and potential use in drug design.

Uses

Used in Pharmaceutical Research and Development:
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid is used as a chiral building block for the synthesis of new drugs targeting specific biological pathways or processes. Its unique structure and stereochemistry allow for the development of innovative therapeutic agents with potential applications in various medical fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid serves as a valuable compound for the design and optimization of novel drug candidates. Its biphenyl group and stereocenters can be exploited to create molecules with enhanced selectivity, potency, and pharmacokinetic properties, ultimately leading to more effective treatments for various diseases and conditions.

Upstream product

• 31603-77-7 4-biphenylacetonitrile 
• 5728-52-9 (4-biphenylyl)acetic acid 

Downstream Products

• 752174-62-2 (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester 
• 149690-12-0 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride 
• 149709-62-6 α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate 

Relevant articles and documents

Preparation method of neprilysin inhibitor intermediate

The invention discloses a preparation method for an enkephalinase inhibitor intermediate. According to the preparation method, a target compound with a formula I as described in the specification is prepared by using a compound as shown in a formula IV which is described in the specification as an initial material through a reaction with few steps, wherein the compound with the formula I can be used for preparation of an enkephalinase inhibitor drug namely Sacubtril. In the formula I and the formula IV, R is selected from the group consisting of H, methyl, ethyl or other lower alkyl.

SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF

The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril. The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost, environment friendly, and etc., which is very suitable for industrial production.

Sacubitril intermediate and preparation method thereof

The invention relates to a sacubitril intermediate and a preparation method thereof, the sacubitril intermediate is a compound shown as formula (04), and the sacubitril intermediate is prepared by deprotection reaction of a compound shown as formula (03). Further, the invention also provides the preparation method of the compound shown as the formula (04) as the intermediate. The method has the advantages of easy availability of raw materials, simple process, economy and environmental protection, and the like, and is very suitable for industrial production.