1038919-63-9

Basic information

• Product Name: (R)-5-Bromo-2,3-dihydro-1H-inden-1-ol
• Synonyms: (R)-5-Bromo-2,3-dihydro-1H-inden-1-ol
• CAS NO: 1038919-63-9
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.07116
• Mol File: 1038919-63-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 307.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.617±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.05±0.20(Predicted)
• CAS DataBase Reference: (R)-5-Bromo-2,3-dihydro-1H-inden-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-Bromo-2,3-dihydro-1H-inden-1-ol(1038919-63-9)
• EPA Substance Registry System: (R)-5-Bromo-2,3-dihydro-1H-inden-1-ol(1038919-63-9)

Safety Data

• Hazardous Substances Data: 1038919-63-9(Hazardous Substances Data)

Usage

Description

(R)-5-Bromo-2,3-dihydro-1H-inden-1-ol is a chiral chemical compound with the molecular formula C9H9BrO. It is the (R) enantiomer of the compound and is known for its unique properties due to its chiral nature.

Uses

Used in Pharmaceutical Industry:
(R)-5-Bromo-2,3-dihydro-1H-inden-1-ol is used as a building block for the synthesis of various pharmaceuticals. Its chiral nature allows it to be a valuable component in the development of drugs with specific therapeutic effects.
Used in Agrochemical Industry:
(R)-5-Bromo-2,3-dihydro-1H-inden-1-ol is also used as a building block in the synthesis of agrochemicals. Its unique properties can contribute to the development of effective and targeted agrochemical products.
Used in Fine Chemicals Industry:
(R)-5-Bromo-2,3-dihydro-1H-inden-1-ol serves as a precursor to a variety of important organic molecules in the fine chemicals industry. Its versatility and chiral nature make it a valuable asset in the synthesis of specialty chemicals.
Used in Asymmetric Catalysis:
(R)-5-Bromo-2,3-dihydro-1H-inden-1-ol has potential applications in the field of asymmetric catalysis. Its chiral nature allows it to be used in the development of catalysts that can selectively produce specific enantiomers of a compound, which is crucial in many chemical reactions.
Used in Asymmetric Synthesis Research:
Due to its chiral nature, (R)-5-Bromo-2,3-dihydro-1H-inden-1-ol is of interest to researchers studying asymmetric synthesis and chiral resolution. It can be used as a model compound to understand the mechanisms and develop new methods for the synthesis of enantiomerically pure compounds.

Upstream product

• 34598-49-7 5-Bromo-1-indanone 
• 34598-50-0 5-bromo-1-indanol 
• 76-86-8 Triphenylsilyl chloride 

Downstream Products

• 1038919-74-2 (S)-5-benzyl-3-(5-bromo-2,3-dihydro-1H-inden-1-yl)-2-ethyl-7-methyl-3H-imidazo[4,5-b]pyridine 
• 903557-29-9 (S)-5-bromoindan-1-ylamine 
• 903557-31-3 tert-butyl N-[(S)-5-bromo-2,3-dihydroinden-1-yl]carbamate 
• 1421597-43-4 C₂₅H₂₁BrF₃N₃O 
• 1421597-42-3 C₂₅H₂₄BrN₃O 
• 1421597-41-2 C₂₄H₂₁BrFN₃O 
• 1421597-40-1 C₂₅H₂₁BrF₃N₃O₂ 
• 1421597-39-8 C₂₅H₂₁BrF₃N₃O 
• 1421597-32-1 C₂₆H₂₄BrN₃O₃ 
• 1421597-30-9 C₂₄H₂₂BrN₃O 
• 1038919-82-2 (R)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-ol 
• 1310692-60-4 (S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-2-ethyl-5,6,7-trimethyl-3H-imidazo[4,5-b]pyridine 
• 1310692-59-1 (S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-2-cyclopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine 
• 1310692-67-1 (S)-2-(1-(2-ethyl-5-isobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-2,3-dihydro-1H-inden-5-yl)benzoic acid 

Relevant articles and documents

Kinetic resolution of racemic benzofused alcohols catalysed by HMFO variants in presence of natural deep eutectic solvents

5-Hydroxymethylfurfural oxidase (HMFO) has demonstrated to be a useful biocatalyst for the selective oxidation of alcohols employing oxygen as mild oxidant with no requirement of expensive organic cofactors. This wild-type HMFO biocatalyst and an engineered thermostable variant have been tested in the kinetic resolution of different benzofused alcohols. The use of natural deep eutectic solvents was also explored in HMFO-catalysed oxidation of alcohols. The oxidation of racemic 1-indanol showed a higher conversion and selectivity in presence of 60% v/v of different NADES, especially for those containing carbohydrates. By choosing properly the biocatalyst and the NADES, good enantioselectivity values can be obtained, demonstrating the advantages of employing these neoteric solvents in biocatalysed processes.

Chiral amino-pyridine-phosphine tridentate ligand, manganese complex, and preparation method and application thereof

The invention discloses a chiral amino-pyridine-phosphine tridentate ligand, a manganese complex, and a preparation method and application thereof. The chiral amino-pyridine-phosphine tridentate ligand is shown as a formula II, and the manganese complex of the chiral amino-pyridine-phosphine tridentate ligand can be used for efficiently catalyzing and hydrogenating ketone compounds to prepare chiral alcohol compounds in a high enantioselectivity mode. The chiral amino-pyridine-phosphine tridentate ligand and the manganese complex are simple in synthesis process, good in stability, high in catalytic activity and mild in reaction conditions.

Silylative Kinetic Resolution of Racemic 1-Indanol Derivatives Catalyzed by Chiral Guanidine

Efficient kinetic resolution of racemic 1-indanol derivatives was achieved using triphenylchlorosilane by asymmetric silylation in the presence of chiral guanidine catalysts. The chiral guanidine catalyst (R,R)-N-(1-(β-naphthyl)ethyl)benzoguanidine was found to be highly efficient as only 0.5 mol % catalyst loading was sufficient to catalyze the reaction of various substrates with appropriate conversion and high s-values (up to 89). This catalyst system was successfully applied to the gram-scale silylative kinetic resolution of racemic 1-indanol with high selectivity.