103587-51-5

Basic information

• Product Name: O-(tert-butyldiphenylsilyl)hydroxylamine
• Synonyms: O-(tert-butyldiphenylsilyl)hydroxylamine;HydroxylaMine, O-[(1,1-diMethylethyl)diphenylsilyl]-;O-(t-Butyldiphenylsilyl)hydroxylamine;O-(tert-Butyldiphenylsilyl)
• CAS NO: 103587-51-5
• Molecular Formula: C₁₆H₂₁NOSi
• Molecular Weight: 271
• Mol File: 103587-51-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 90 °C
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: Chloroform, Ethyl Acetate (Slightly)
• CAS DataBase Reference: O-(tert-butyldiphenylsilyl)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(tert-butyldiphenylsilyl)hydroxylamine(103587-51-5)
• EPA Substance Registry System: O-(tert-butyldiphenylsilyl)hydroxylamine(103587-51-5)

Safety Data

• Hazardous Substances Data: 103587-51-5(Hazardous Substances Data)

Usage

Description

O-(tert-butyldiphenylsilyl)hydroxylamine is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique structure, which includes a tert-butyldiphenylsilyl group attached to a hydroxylamine moiety. This structure endows it with specific reactivity and properties that make it valuable in the development of certain medications.

Uses

Used in Pharmaceutical Synthesis:
O-(tert-butyldiphenylsilyl)hydroxylamine is used as an intermediate in the synthesis of N-Hydroxy Vortioxetine O-β-D-Glucuronide Sodium Salt (H996005). O-(tert-butyldiphenylsilyl)hydroxylamine is a metabolite of Vortioxetine (V766000, HBr), a multimodal serotonergic agent with a wide range of applications in the treatment of various conditions related to the serotonin system.
In the pharmaceutical industry, O-(tert-butyldiphenylsilyl)hydroxylamine plays a vital role in the development of Vortioxetine and its derivatives. Vortioxetine is known for its ability to inhibit multiple serotonin receptors, including 5-HT1A, 5-HT1B, 5-HT3A, and 5-HT7, as well as the serotonin transporter (SERT). This unique profile makes Vortioxetine a promising candidate for the treatment of various psychiatric and neurological disorders, such as depression, anxiety, and obsessive-compulsive disorder.
The use of O-(tert-butyldiphenylsilyl)hydroxylamine in the synthesis of Vortioxetine and its metabolites highlights its importance in the development of novel therapeutic agents with potential applications in the treatment of a wide range of conditions. Its unique structural features and reactivity make it a valuable component in the design and synthesis of new drugs targeting the serotonin system.

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 847797-40-4 C₄₂H₄₇NO₅Si 
• 263888-07-9 O-tert-butyldiphenylsilyl hydrocinnamohydroxamate 
• 1370556-92-5 C₂₁H₂₅N₃O₂SSi 
• 118684-94-9 O-(tert-butyldiphenylsilyl)-N-<1-methyl-1-<4-(benzyloxy)phenyl>ethyl>hydroxylamine 

Relevant articles and documents

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Thiyl radical-mediated cyclization of ω-alkynyl O-tert-butyldiphenylsilyloximes

ω-Alkynyl O-tert-butyldiphenylsilyloximes, upon treatment with odorless 4-tert-butylbenzenethiol in the presence of azobisisobutyronitrile (AIBN) in refluxing benzene, underwent addition of a thiyl radical to the alkynyl group followed by radical cyclizat

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