1035555-51-1 Usage
Description
(R)-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione is a complex organic molecule characterized by a pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione backbone. It features a 2,3-dihydroxypropyl group, a 2-fluoro-4-iodophenylamino group, and a methyl group at the 8-position. (R)-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione is likely to possess significant biological activity, making it a candidate for research and pharmaceutical development. Further investigation is necessary to determine its specific mode of action and potential applications.
Uses
Used in Pharmaceutical Research:
(R)-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione is used as a research compound for exploring its biological activity and potential therapeutic applications. Its unique structure and functional groups may offer insights into new drug development strategies.
Used in Drug Development:
In the pharmaceutical industry, (R)-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione is used as a lead compound for the development of new medications. Its structure may be optimized to target specific biological pathways or receptors, potentially leading to the creation of novel therapeutic agents.
Used in Chemical Synthesis:
(R)-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione may also be utilized as a synthetic intermediate or building block in the synthesis of other complex organic molecules. Its unique functional groups can be exploited to create a variety of derivatives with different properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1035555-51-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,5,5,5 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1035555-51:
(9*1)+(8*0)+(7*3)+(6*5)+(5*5)+(4*5)+(3*5)+(2*5)+(1*1)=131
131 % 10 = 1
So 1035555-51-1 is a valid CAS Registry Number.
1035555-51-1Relevant articles and documents
Process research and kilogram synthesis of an investigational, potent MEK inhibitor
Zhao, Yuxin,Zhu, Lei,Provencal, David P.,Miller, Todd A.,O'Bryan, Colin,Langston, Marianne,Shen, Ming,Bailey, Dan,Sha, Dezhi,Palmer, Travis,Ho, Thuy,Li, Mai
, p. 1652 - 1659 (2013/02/23)
TAK-733 (1) is an investigational, novel MEK kinase inhibitor that bears a 6-fluoropyridopyrimidone core. Process research of 1 was conducted, and an efficient, scalable route was developed. The key intermediate, a multisubstituted fluoropyridone, was formed in one pot via a three-step cascade reaction: condensation between a-fluoromalonate and malononitrile, methyl amide formation, and intramolecular cyclization. Chlorination of the hydroxyl functionality and cyclization with formic acid provided the desired pyridopyrimidone core in high yield. Subsequent N-alkylation with the nosylate of (R)-glycerol acetonide and displacement of the chlorine with 2-fluoro-4-iodoaniline proceeded successfully with good yields. Final acid-catalyzed deprotection of the acetonide functionality followed by a controlled crystallization protocol afforded the active pharmaceutical ingredient (API) with the desired polymorph. Compared to the initial synthesis, this route was more concise (six steps compared to the original nine steps), and the overall yield was improved significantly (from 3% to 25%). These improvements allowed for production of multikilograms of 1.
MAPK/ERK KINASE INHIBITORS
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Page/Page column 110, (2008/12/07)
Compounds of the following formula are provided for use with MEK (I): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
