1032824-54-6 Usage
Description
GSK1292263 (HCl) is a selective and potent inhibitor of the receptor-interacting protein 1 (RIP1) kinase, which is an essential component of the tumor necrosis factor (TNF) signaling pathway. This pathway plays a crucial role in inflammation and cell death. GSK1292263 (HCl) effectively blocks RIP1 kinase activity, leading to decreased production of pro-inflammatory cytokines and inhibition of programmed cell death.
Uses
Used in Pharmaceutical Industry:
GSK1292263 (HCl) is used as an anti-inflammatory agent for its ability to decrease the production of pro-inflammatory cytokines and inhibit programmed cell death, making it a potential therapeutic option for inflammatory and autoimmune diseases.
Used in Autoimmune Disease Treatment:
GSK1292263 (HCl) is used as a treatment for autoimmune diseases due to its potential to modulate the TNF signaling pathway, which is implicated in the pathogenesis of these conditions.
Used in Tissue Damage Prevention:
GSK1292263 (HCl) is used as a preventative measure for tissue damage associated with ischemia-reperfusion injury, as its inhibition of RIP1 kinase can help protect against cell death and inflammation in these scenarios.
Used in Cancer Treatment Research:
GSK1292263 (HCl) is used as a subject of research in cancer treatment, given its potential role in regulating cell survival and proliferation through its effect on RIP1 kinase.
Check Digit Verification of cas no
The CAS Registry Mumber 1032824-54-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,2,8,2 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1032824-54:
(9*1)+(8*0)+(7*3)+(6*2)+(5*8)+(4*2)+(3*4)+(2*5)+(1*4)=116
116 % 10 = 6
So 1032824-54-6 is a valid CAS Registry Number.
1032824-54-6Relevant articles and documents
BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS
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Page/Page column 82, (2010/03/02)
The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.