103094-30-0

Basic information

• Product Name: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: 4-92-ChloroPhenyl)-3-EthoxyCarbonyl-5-MethoxyCarbonyl-6-Methyl-2-(2-PhthalimidoEthoxy)Methyl-1,4-DihydroPyridine,AmlodipineBesylate;4-(2-Chloro Phenyl)-3-Ethoxycarbonyl-5-Methoxy carbonyl-6-Methyl-2-(2-Phthalimido Ethoxy) Methyl-1,4-Dihydro Pyridine;3-ETHYL-5-METHYL-4-(2-CHLOROPHENYL)-2-(2,2-DIETHOXY-ETHOXYMETHYL)-6-METHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICARBOXYLATE;3-ETHYL-5-METHYL-4-(2-CHLOROPHENYL)-2-(2,2-DIETHOXY-ETHOXYMETHYL)-6-METHYL-1,4-DIHYDRO-PYRIDINE-3,5-DIDARBOXYLATE;3-Ethyl-5-methyl-4-(2-Chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-Methyl-1,4-Dihydro-Pyridine-3,5-Didarboxylate;3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 103094-30-0
• Molecular Formula: C24H32ClNO7
• Molecular Weight: 481.96638
• Mol File: 103094-30-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 553.084 °C at 760 mmHg
• Flash Point: 288.295 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate(103094-30-0)
• EPA Substance Registry System: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate(103094-30-0)

Safety Data

• Hazardous Substances Data: 103094-30-0(Hazardous Substances Data)

Usage

General Description

The chemical 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate is a complex compound with a dihydropyridine structure. It contains an ethyl and methyl group, as well as a 2-chlorophenyl moiety. Additionally, it has a diethoxy-ethoxymethyl group attached to the dihydropyridine ring. This chemical is often used as a calcium channel blocker, and it has potential applications in the treatment of hypertension, angina pectoris, and other cardiovascular conditions. Its unique structure and pharmacological properties make it a valuable compound for pharmaceutical research and drug development.

InChI:InChI=1/C24H32ClNO7/c1-6-31-19(32-7-2)14-30-13-18-22(24(28)33-8-3)21(16-11-9-10-12-17(16)25)20(15(4)26-18)23(27)29-5/h9-12,19,21,26H,6-8,13-14H2,1-5H3

Upstream product

• 14205-39-1 methyl 3-aminocrotonate 
• 67593-46-8 methyl (Z)-2-acetyl-3-(2-chlorophenyl)acrylate 
• 265136-65-0 ethyl (E)-3-amino-4-[2-(phthalimido)ethoxy]crotonate 
• 85-44-9 phthalic anhydride 
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• 1074-82-4 potassium phtalimide 
• 400024-08-0 ethyl 2-(2-chlorobenzylidene)-4-[(2-phthalimido)ethoxy]acetoacetate 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 88150-75-8 ethyl 4-[2-(phthalimido)ethoxy]acetoacetate 
• 89-98-5 2-chloro-benzaldehyde 
• 21731-17-9 methyl 3-aminocrotonate 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 

Downstream Products

• 93849-02-6 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 

Relevant articles and documents

Method for preparing amlodipine besylate intermediate by using micro-reaction device

The invention provides a method for producing an amlodipine besylate intermediate by using a micro-reaction device. According to the method, o-chlorobenzaldehyde is used as a raw material, the amlodipine besylate intermediate is rapidly and safely prepared by using the micro-reaction device, and the method has the advantages of high reaction conversion rate, simple post-treatment, small reaction volume, short reaction time, low energy consumption and the like, and has relatively high commercial value.

Synthesis process of amlodipine besylate

The invention discloses a synthesis process of amlodipine besylate, relates to the technical field of medicine synthesis and solves the problems of low product purity and poor product quality controllability of products prepared by the existing synthesis process. According to the synthesis process, phthalic anhydride is used as raw materials; the parameters of the synthesis process are controlled;the technical flow process is shortened; the synthesis cost is reduced; the product yield is as high as 91 percent; the purity of the prepared amlodipine besylate is as high as 99.5 percent. The self-made amlodipine besylate are used as raw materials for further preparing the amlodipine besylate tablets; the product cost is reduced; the product quality controllability is high.

Using the new crystal form [...] and production of high-purity [...]

PROBLEM TO BE SOLVED: To provide a process for producing high-purity phthaloyl amlodipine for synthesis of an amlodipine besilate having excellent purity as a medicine.SOLUTION: Provided are TW-A type and TW-B type crystal forms of highly pure phthaloyl amlodipine. In powder X-ray diffraction, the TW-A type phthaloyl amlodipine has diffraction peaks at 2θ(°)=8.7±0.2, 11.0±0.2, 13.4±0.2, 15.7±0.2, and 24.6±0.2. In powder X-ray diffraction, the TW-B type phthaloyl amlodipine has diffraction peaks at 2θ(°)=6.6±0.2, 9.9±0.2, 11.1±0.2, 17.3±0.2, and 24.4±0.2.