102729-42-0Relevant articles and documents
Iridium-Catalyzed [4+2] Annulations of β-Keto Sulfoxonium Ylides and o-Phenylenediamines: Mild and Facile Synthesis of Quinoxaline Derivatives
Che, Tong,Kang, Hua-Jie,Peng, Dongming,Shu, Bing,Song, Jia-Lin,Wang, Xiao-Tong,Xie, Hui,Zhang, Luyong,Zhang, Shang-Shi,Zhong, Mei
, (2020/06/25)
A synthetic method for quinoxaline derivatives from the [4+2] annulation of β-keto sulfoxonium ylides and o-phenylenediamine by using (Cp*IrCl2)2 catalyst is described. This novel protocol features mild reaction conditions, moderate to excellent yields, wide substrate scope, and high functional-group compatibility. Moreover, this cyclization strategy was successfully applied in late-stage modification for structurally complex bioactive compounds.
One-pot copper-catalyzed three-component synthesis of quinoxalines by condensation and C-N bond formation
Yuan, Hua,Li, Kangning,Chen, Yongxin,Wang, Yu,Cui, Jiaojiao,Chen, Baohua
supporting information, p. 2315 - 2319 (2013/11/06)
A novel way of synthesizing quinoxalines has been developed that involves condensation and C-N bond formation in a copper-catalyzed, one-pot, three-component reaction. The reaction was optimized when 2-iodoanilines (1.0 equiv), arylacetaldehydes (2.0 equiv), sodium azide (1.2 equiv), CuI (10 mol%), DMEDA (10 mol%), and K2CO3 (1.0 equiv) were reacted in DMSO at 80 °C for 20 hours. This approach was used to directly synthesize a variety of quinoxalines in moderate to good yields. Georg Thieme Verlag KG Stuttgart.
2-Phenyl-(6(7)-R-substituted quinoxalines N-oxides. Synthesis, structure elucidation and antimicrobial activity
Loriga,Nuvole,Paglietti,Fadda,Zanetti
, p. 527 - 532 (2007/10/02)
A certain number of isomeric 2-phenylquinoxalines N-oxides bearing substituents at position 6/7 were prepared in order to investigate anti-microbial activity. The effect of some electron-withdrawing groups seem to increase an anti-Trichomonas vaginalis ac
