10257-32-6Relevant articles and documents
Reactions of Adenine Nucleosides with Aqueous Alkalies: Kinetic and Mechanism
Lehikoinen, Pertti,Mattinen, Jorma,Loennberg, Harri
, p. 3819 - 3823 (1986)
The hydrolysis of adenosine in aqueous alkali has been studied by liquid chromatography (LC), NMR spectroscopy, and isotopic labeling techniques.The first step of the multistage reaction pathway has been shown to be a nucleophilic attack of hydroxide ion on the C8 atom with concomitant opening of the imidazole ring.The equilibrium mixture of 4-amino-5-formamido-6-(ribosylamino)pyrimidines obtained undergoes three competitive reactions, viz., intramolecular cyclization to adenine nucleosides and N6-ribosyladenines and degradation to nonchromophoric products, most probably via intermediary formation of 4,5-diamino-6-(ribosylamino)pyrimidines.Isomeric N6-ribosyladenines are further hydrolyzed to adenine and D-ribose.The rate constants for the different partial reactions have been determined at various concentrations of hydroxide ion.The mechanisms of individual steps are discussed.Comparative kinetic studies with 2'-deoxy-, 2',3'-O-isopropylidene-, and 5'-O-methyladenosine and 9-β-D-arabinofuranosyladenine and its 5'-O-methyl derivative are interpreted to indicate that the glycon moiety hydroxyl groups do not play any important role in the alkaline cleavage of adenine nucleosides.
New flavonoid glycosides from Xanthium strumarium with their protein tyrosine phosphatase 1B inhibitory activity
Jiang, Pei-Jing,Lu, Mei-Jiao,Xi, Yi-Yuan,Chen, Jun,Zheng, Ju-Jia,Xu, Xiang-Wei
, p. 45 - 51 (2021/01/25)
Two new flavonoid glycosides named 6-hydroxy-3-methoxy-apigenin 7-O-α-?-rhamnopyranoside (1) and 3-hydroxyl-apigenin 8-C-β-?-xylopyranoside (2), along with five known compounds (3-7), were isolated from Xanthium strumarium. Their structures were elucidate
A new triterpenoid saponin from Glinus oppositifolius
Phan, Thuy Thanh,Do, Lien T. M.,Phung, Trung Van,Nguyen, Thu Thi Hoai,Huynh, Vinh N.,Ngo, Duong Thi Thuy,Nguyen, Kim Phi Phung,Nguyen, Tuyet Thi Anh
, p. 171 - 176 (2020/07/03)
From the ethanol extract of Glinus oppositifolius, collected at Phu Yen province, Viet Nam, one new triterpenoid saponin (1) and four known compounds (2–5) were isolated. By means of NMR and HR-ESI-MS analyses, their structure was elucidated as 3-O-(β-D-xylopyranosyl-(1→3)-β-D-xylopyranosyl)spergulagenin A or glinusopposide V (1), glinusopposide L (2), spergulin B (3), vitexin (4) and astralagin (5). Two compounds (1–2) showed weak inhibitory activity against α-glucosidase.