1023595-17-6 Usage
Description
Indazole-4-boronic acid, hydrochloride is an organic compound that serves as a versatile reagent in the synthesis of various pharmaceutical compounds. It is a white solid and may contain varying amounts of anhydride. This chemical is known for its ability to form stable boron-carbon bonds, which are crucial in the development of new drugs and materials.
Uses
Used in Pharmaceutical Industry:
Indazole-4-boronic acid, hydrochloride is used as a reactant for the preparation of trisubstituted pyrimidines, which are known as phosphatidylinositol 3-kinase inhibitors. These inhibitors play a significant role in the treatment of various diseases, including cancer, by targeting the enzymes involved in cell signaling pathways.
Indazole-4-boronic acid, hydrochloride is also used as a reactant for the preparation of bisphosphonate inhibitors of human farnesyl pyrophosphate synthase. These inhibitors are essential in the development of drugs for the treatment of osteoporosis and other bone-related disorders, as they help regulate the activity of enzymes involved in bone metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 1023595-17-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,3,5,9 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1023595-17:
(9*1)+(8*0)+(7*2)+(6*3)+(5*5)+(4*9)+(3*5)+(2*1)+(1*7)=126
126 % 10 = 6
So 1023595-17-6 is a valid CAS Registry Number.
InChI:InChI=1S/C7H7BN2O2/c11-8(12)6-2-1-3-7-5(6)4-9-10-7/h1-4,11-12H,(H,9,10)
1023595-17-6Relevant articles and documents
Preparation method of nitrogen unsubstituted pyrazole and indazole boric acid
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Paragraph 0052-0054; 0058-0060, (2020/01/12)
The invention discloses a method for preparing nitrogen unsubstituted pyrazole and indazole boric acid. Nitrogen unsubstituted halogenated pyrazole and a derivative thereof, or nitrogen unsubstitutedhalogenated indazole and a derivative of the nitrogen unsubstituted halogenated indazole react with triisopropylchlorosilane in an organic solvent to generate a triisopropylsilyl protected halogenatedpyrazole or halogenated indazole compound, then a lithium-bromine exchange reaction is carried out with n-butyl lithium, a borate is added to introduce boron atoms, and the nitrogen unsubstituted pyrazole or indazole boric acid is obtained in high yield after hydrolysis.
