10209-10-6Relevant articles and documents
A stereocontrolled synthesis of cefprozil and related cephems via allenylazetidinones
Kant, Joydeep,Farina, Vittorio
, p. 3563 - 3566 (1992)
A new method for the preparation of cephalosporins bearing carbon substituents of choice at C-3 is described. The approach involves 1,4-conjugate addition of an organocuprate to an allenylazetidinone to form a carbon-carbon bond followed by ring closure via intramolecular sulfenylation reaction.
A synthetic approach to 3-substituted cephalosporins: Carbon-carbon bond formation at C(3) of the cephem via organocuprate chemistry
Kant
, p. 2296 - 2301 (2007/10/02)
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Reactions of organocuprates with vinyl-triflates and related cephems: A novel approach to 3-substituted cephalosporins
Kant, Joydeep,Sapino Jr., Chester,Baker, Stephen R.
, p. 3389 - 3392 (2007/10/02)
Vinyl-triflates and related 3-substituted cephems readily undergo addition-elimination reactions with a variety of organocuprates to form new carbon-carbon bonds. This chemistry presents a novel approach to the synthesis of 3-alkyl, 3-aryl, and 3-alkenylcephalosporins.