101667-97-4Relevant articles and documents
Synthesis and antitumor activity evaluation of some thienopyrimidine derivatives
Abou-Elmagd, Wael S. I.,Abou-Elregal, Mohsen K.,Hemdan, Magdy M.,Mohamed, Amira T. A.,Samir, Sandy S.,Youssef, Ahmed S. A.
, (2019)
Some novel thienopyrimidine derivatives were synthesized via the reaction of 5- methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carbohydrazide with different carbonyl compounds such as anhydrides, acid chlorides, carbon disulfide, phenyl isothiocyanate, triethyl orthoformate, diethyl acetylene dicarboxylate, acetylacetone, pyrazole-4-carboxaldehyde, and isatin. Also, the reaction of this carbohydrazide derivative with sodium nitrite in the presence of hydrochloric acid to give the corresponding azide derivative was discussed. The latter azide derivative was reacted with different amines to give the corresponding diheteryl urea derivatives. The antitumor activity evaluation of some representative examples of the synthesized compounds was examined against HePG2 and MCF-7 cell lines. Some of the newly synthesized compounds showed significant activity.
Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening
Borthwick, Jennifer A.,Ancellin, Nicolas,Bertrand, Sophie M.,Bingham, Ryan P.,Carter, Paul S.,Chung, Chun-Wa,Churcher, Ian,Dodic, Nerina,Fournier, Charlène,Francis, Peter L.,Hobbs, Andrew,Jamieson, Craig,Pickett, Stephen D.,Smith, Sarah E.,Somers, Donald O'N.,Spitzfaden, Claus,Suckling, Colin J.,Young, Robert J.
, p. 2452 - 2467 (2016/04/10)
Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified using fragment screening, are described. This was carried out using a combination of STD-NMR, thermal melt (Tm), and biochemical assays to identify compounds that b
THIENOPYRIMIDINES CONTAINING A SUBSTITUTED ALKYL GROUP FOR PHARMACEUTICAL COMPOSITIONS
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Page/Page column 53, (2011/09/30)
The present invention relates to novel thienopyhmidine compounds of general formula pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.