1013883-02-7 Usage
Description
FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE is a complex organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and chemicals. It is characterized by its unique molecular structure, which includes a protected amino acid and an ethoxy group, making it a versatile building block for the development of new compounds.
Uses
Used in Pharmaceutical Industry:
FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE is used as an organic synthesis intermediate for the development of new pharmaceutical compounds. Its unique structure allows for the creation of a wide range of molecules with potential therapeutic applications, making it a valuable asset in the drug discovery process.
Used in Chemical Production:
FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE is also used as a pharmaceutical intermediate in the chemical production process. Its role in the synthesis of various compounds makes it an essential component in the manufacturing of a diverse array of products, from pharmaceuticals to specialty chemicals.
Used in Laboratory Research and Development:
FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE is a key component in laboratory research and development processes. Its unique properties and reactivity make it an ideal candidate for exploring new chemical reactions and synthesizing novel compounds, contributing to the advancement of scientific knowledge and the development of innovative products.
Synthesis
Add O-[2-[[tert-butoxycarbonyl]amino]ethyl]-L-tyrosine (3.24g, 10mmol) in a 100mL three-necked flask equipped with magnetic stirring and a thermometer, with a mass concentration of 5 · 5% 21.2g of sodium carbonate aqueous solution, 20mL of 9-fluorenylmethyl-N-succinimidyl carbonate (3.37g, 10mmol) in tetrahydrofuran solution was added dropwise at room temperature, after the addition, the amidation reaction was carried out at room temperature, monitored by TLC To the end of the reaction. Concentrated to remove part of the solvent, acidified with 2N hydrochloric acid to pH 6~7, extracted with ethyl acetate, washed with saturated brine, concentrated, beaten with petroleum ether, filtered and dried to obtain a white solid O-alkyl-N-[ Fluorenylmethyloxycarbonyl]-L-tyrosine is 4.68g, the yield is 85.7%, the HPLC purity is 99.8%, and the ee value is 99.8%.
Check Digit Verification of cas no
The CAS Registry Mumber 1013883-02-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,3,8,8 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1013883-02:
(9*1)+(8*0)+(7*1)+(6*3)+(5*8)+(4*8)+(3*3)+(2*0)+(1*2)=117
117 % 10 = 7
So 1013883-02-7 is a valid CAS Registry Number.
1013883-02-7Relevant articles and documents
Preparation method of L-tyrosine derivative
-
, (2021/06/09)
The invention discloses a preparation method of an L-tyrosine derivative. The L-tyrosine derivative is O-alkyl-N-[fluorenylmethoxycarbonyl]-L-tyrosine, L-tyrosine is used as a starting material, the O-alkyl-N-[fluorenylmethoxycarbonyl]-L-tyrosine is prepared through esterification, amidation, etherification/hydrolysis and amidation in sequence, the total yield of the target product can reach 61.5%, and the ee value can reach 99% or above. The preparation method disclosed by the invention has the advantages of cheap and easily available raw materials, lower cost and the like, for example, separation of triphenylphosphine oxide is avoided through etherification reaction. The method has the advantages of simple process, short route, mild reaction conditions and the like, for example, etherification and hydrolysis adopt a one-pot method; and the whole technological process generates few three wastes, the product yield and purity are high, and the method is suitable for industrial production.
