101337-89-7

Basic information

• Product Name: 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid 1-oxide
• CAS NO: 101337-89-7
• Molecular Formula: C₁₇H₁₈FN₃O₄S
• Molecular Weight: 379.4059
• Mol File: 101337-89-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 673.3°C at 760 mmHg
• Flash Point: 361°C
• Density: 1.64g/cm³
• Vapor Pressure: 4.8E-19mmHg at 25°C
• Refractive Index: 1.744
• CAS DataBase Reference: 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid 1-oxide(101337-89-7)
• EPA Substance Registry System: 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid 1-oxide(101337-89-7)

Safety Data

• Hazardous Substances Data: 101337-89-7(Hazardous Substances Data)

Upstream product

• 101337-97-7 ethyl 10-chloro-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylate 
• 101337-81-9 10-chloro-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylic acid 
• 101337-95-5 8-chloro-7-fluoro-3-oxo-3,4-dihydro-2H-1,4-benzothiazine 
• 101337-96-6 8-chloro-7-fluoro-3,4-dihydro-2H-1,4-benzothiazine 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 109-01-3 1-methyl-piperazine 
• 101337-84-2 10-chloro-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylic acid 1-oxide 

Downstream Products

• 101363-10-4 rufloxacin 

Relevant articles and documents

Quinolonecarboxylic Acids. 2. Synthesis and Antibacterial Evaluation of 7-Oxo-2,3-dihydro-7H-pyridobenzothiazine-6-carboxylic Acids

A series of pyridobenzothiazine acid derivatives was synthesized and their in vitro antibacterial activity was evaluated.The 1,4-benzothiazine intermediates, which by Gould-Jacobs quinoline synthesis produced pyridobenzothiazine acids, were prepared by hydrolytic basic cleavage of substituted 2-aminobenzothiazoles and successive cyclocondensation with 1-bromo-2-chloroethane or alternatively with monochloroacetic acid, hence reduction by LiAlH4.The pyridobenzothiazine acids 10c, 30, and 31 show potent antibacterial activities against Gram-positive and Gram-negative pathogens.Structure-activity relationships are discussed.The compound 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyridobenzothiazine-6-carboxylic acid (31) (MF-934) has been found to possess, together with the antibacterial activity, a weak acute toxicity and interesting pharmacokinetic characteristics in several animal species (rat, dog, monkey, man).