100872-83-1 Usage
Description
ML346 is an activator of the heat shock response, which enhances the expression of heat shock proteins (HSP70, HSP40, and HSP27) and promotes the expression of oxidative stress response genes (HO1, GCLM, and BiP). It is effective in protecting cells from heat shock-induced death and H2O2-induced apoptosis, as well as in promoting the folding of metastable proteins in conformational disease models. ML346 also demonstrates potential in reducing aggregate formation in neurodegenerative diseases and correcting protein trafficking in certain genetic disorders.
Uses
Used in Pharmaceutical Industry:
ML346 is used as a therapeutic agent for the treatment of neurodegenerative diseases, such as Huntington's disease, by reducing aggregate formation in cellular models expressing human Huntingtin exon 1 with a 74 glutamine expansion at a concentration of 10 μM.
Used in Genetic Disorder Treatment:
ML346 is used as a treatment for cystic fibrosis, particularly for patients carrying the F508 deletion (ΔF508-CFTR) mutation. It helps correct the trafficking of the cystic fibrosis transmembrane conductance regulator proteins, leading to increased cell surface expression and improved functionality.
Used in Cellular Protection:
ML346 is used as a protective agent in cell cultures, particularly in mouse embryonic fibroblasts (MEFs), to prevent severe heat shock-induced death and H2O2-induced apoptosis by inducing the expression of heat shock proteins and oxidative stress response genes.
Used in Conformational Disease Research:
ML346 is used as a research tool in the study of conformational diseases, where it promotes the folding of metastable proteins and helps understand the underlying mechanisms of protein misfolding and aggregation.
Check Digit Verification of cas no
The CAS Registry Mumber 100872-83-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,8,7 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 100872-83:
(8*1)+(7*0)+(6*0)+(5*8)+(4*7)+(3*2)+(2*8)+(1*3)=101
101 % 10 = 1
So 100872-83-1 is a valid CAS Registry Number.
100872-83-1Relevant articles and documents
SHIKIMATE PATHWAY INHIBITORS AND THE USE THEREOF
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Paragraph 0041;0042, (2015/05/26)
The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof. The present invention also provides a synergistic antibacterial composition containing compound
