100431-57-0Relevant articles and documents
Modified Taxols. 2. Oxidation Products of Taxol
Magri, Neal F.,Kingston, David G. I.
, p. 797 - 802 (2007/10/02)
Oxidation of taxol (1) or substituted taxols with Jones' reagent under appropriate conditions yielded 7-oxotaxol (6), 2',7'-dioxotaxol (9), or 2'-oxo-7-acetyltaxol (12).Treatment of 7-oxotaxol with DBU or silica gel yielded a D-secotaxol derivative 14.Hydrogenation of the 2'-acetate derivative of 14 yielded the unstable diketone 16, while hydrogenation of 14 itself followed by workup in methanol gave the lactone 17.
