10028-24-7 Usage
Description
Disodium hydrogen phosphate dihydrate, also known as sodium phosphate dibasic dihydrate, is a hydrate form of disodium hydrogen phosphate. It is a solid chemical compound with various forms, including anhydrous, dihydrate, heptahydrate, and dodecahydrate. The dihydrate form appears as white or almost white, odorless crystals, while the heptahydrate and dodecahydrate forms are colorless crystals or white granular or caked salts that effloresce in warm, dry air.
Uses
1. Used in Pharmaceutical Industry:
Disodium hydrogen phosphate dihydrate is used as a laxative for treating constipation and promoting bowel movements.
2. Used in Medical Treatment:
In the medical field, disodium hydrogen phosphate dihydrate is used as a treatment for ischemic stroke with aptamers targeting toll-like receptor 4 (TLR-4), which helps in reducing the severity of the stroke and improving patient outcomes.
3. Used in Biotechnology and Research:
Disodium hydrogen phosphate dihydrate is used as a reagent for isolating DNA and RNA from bacterial samples of the human gastrointestinal (GI) tract. This application is crucial in molecular biology and microbiology research, as it aids in the identification and analysis of bacterial species present in the GI tract.
Production Methods
Either bone phosphate (bone ash), obtained by heating bones to
whiteness, or the mineral phosphorite is used as a source of tribasic
calcium phosphate, which is the starting material in the industrial
production of dibasic sodium phosphate.
Tribasic calcium phosphate is finely ground and digested with
sulfuric acid. This mixture is then leached with hot water and
neutralized with sodium carbonate, and dibasic sodium phosphate
is crystallized from the filtrate.
Pharmaceutical Applications
Dibasic sodium phosphate is used in a wide variety of pharmaceutical
formulations as a buffering agent and as a sequestering agent.
Therapeutically, dibasic sodium phosphate is used as a mild laxative
and in the treatment of hypophosphatemia.
Dibasic sodium phosphate is also used in food products; for
example as an emulsifier in processed cheese.
Biochem/physiol Actions
Sodium phosphate dibasic dehydrate is an important component of running buffer of denaturing gel electrophoresis.
Safety
Dibasic sodium phosphate is widely used as an excipient in
parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in
many physiological processes since it is the principal anion of
intracellular fluid. Most foods contain adequate amounts of
phosphate, making hypophosphatemia (phosphate deficiency)
virtually unknown except for certain disease states or in patients
receiving total parenteral nutrition. Treatment is usually by the oral
administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed
from the gastrointestinal tract, virtually all of it being excreted in the
urine, and the remainder is excreted in the feces.
Excessive administration of phosphate, particularly intravenously,
rectally, or in patients with renal failure, can cause
hyperphosphatemia that may lead to hypocalcemia or other severe
electrolyte imbalances. Adverse effects occur less frequently
following oral consumption, although phosphates act as mild saline
laxatives when administered orally or rectally. Consequently,
gastrointestinal disturbances including diarrhea, nausea, and
vomiting may occur following the use of dibasic sodium phosphate
as an excipient in oral formulations. However, the level of dibasic
sodium phosphate used as an excipient in a pharmaceutical
formulation is not usually associated with adverse effects.
LD50 (rat, oral): 17 g/kg
storage
The anhydrous form of dibasic sodium phosphate is hygroscopic.
When heated to 40℃, the dodecahydrate fuses; at 100℃ it loses its
water of crystallization; and at a dull-red heat (about 240℃) it is
converted into the pyrophosphate, Na4P2O7. Aqueous solutions of
dibasic sodium phosphate are stable and may be sterilized by
autoclaving.
The bulk material should be stored in an airtight container, in a
cool, dry place.
Incompatibilities
Dibasic sodium phosphate is incompatible with alkaloids, antipyrine,
chloral hydrate, lead acetate, pyrogallol, resorcinol and
calcium gluconate, and ciprofloxacin. Interaction between calcium and phosphate, leading to the formation of insoluble
calcium-phosphate precipitates, is possible in parenteral admixtures.
Regulatory Status
GRAS listed. Accepted in Europe for use as a food additive.
Included in the FDA Inactive Ingredients Database (injections;
infusions; nasal, ophthalmic, oral, otic, topical, and vaginal
preparations). Included in nonparenteral and parenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 10028-24-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,2 and 8 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 10028-24:
(7*1)+(6*0)+(5*0)+(4*2)+(3*8)+(2*2)+(1*4)=47
47 % 10 = 7
So 10028-24-7 is a valid CAS Registry Number.
InChI:InChI=1/2Na.H3O4P.2H2O/c;;1-5(2,3)4;;/h;;(H3,1,2,3,4);2*1H2/q2*+1;;;/p-2
