100126-77-0

Basic information

• Product Name: 2-benzyl-4-chloromethyl[1,3]dioxolane
• Synonyms: 2-benzyl-4-chloromethyl[1,3]dioxolane
• CAS NO: 100126-77-0
• Molecular Weight: 212.676
• Mol File: 100126-77-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-benzyl-4-chloromethyl[1,3]dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-4-chloromethyl[1,3]dioxolane(100126-77-0)
• EPA Substance Registry System: 2-benzyl-4-chloromethyl[1,3]dioxolane(100126-77-0)

Safety Data

• Hazardous Substances Data: 100126-77-0(Hazardous Substances Data)

Upstream product

• 122-78-1 phenylacetaldehyde 
• 96-24-2 3-monochloro-1,2-propanediol 
• 106-89-8 epichlorohydrin 

Downstream Products

• 109337-39-5 ammonium-(2-benzyl-[1,3]dioxolan-4-ylmethyl)-trimethyl; iodide 
• 100618-35-7 (2-benzyl-[1,3]dioxolan-4-ylmethyl)-dimethyl-amine 

Relevant articles and documents

1,3-Dioxolane-based ligands as a novel class of α1-adrenoceptor antagonists

1,3-Dioxolane-based compounds (2-14) were synthesized, and the pharmacological profiles at α1-adrenoceptor subtypes were assessed by functional experiments in isolated rat vas deferens (α1A), spleen (α1B), and aorta (α1D). Compound 9, with a pA2 of 7.53, 7.36, and 8.65 at α1A, α1B, and α1D, respectively, is the most potent antagonist of the series, while compound 10 with a pA2 of 8.37 at α1D subtype and selectivity ratios of 162 (α1D/α1A) and 324 (α1D/α1B) is the most selective. Binding assays in CHO cell membranes expressing human cloned α1-adrenoceptor subtypes confirm the pharmacological profiles derived from functional experiments, although the selectivity values are somewhat lower. Therefore, it is concluded that 1,3-dioxolane-based ligands are a new class of α1-adrenoceptor antagonists.