Name: Amoscanate
SKU: 26328-53-0

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Basic Information

Molecular Structure:
CAS No.:	26328-53-0
Name:	Amoscanate
Article Data:	1

Formula:	C13H9 N3 O2 S
Molecular Weight:	271.299
Synonyms:	Isothiocyanicacid, p-(p-nitroanilino)phenyl ester (8CI);Diphenylamine,4-isothiocyanato-4'-nitro- (8CI);4-(4-Nitroanilino)phenyl isothiocyanate;4-Isothiocyanato-4'-nitrodiphenylamine;4-Nitro-4'-isothiocyanatodiphenylamine;Amoscanate;C 9333Go;CGP 4540;CIBA 9333Go;Nithiocyamine;p-(p-Nitroanilino)phenyl isothiocyanate;
Density:	1.3g/cm³
Melting Point:	196-198°
Boiling Point:	469.7°Cat760mmHg
Flash Point:	237.9°C
Safety:	Mutation data reported. An anthelmintic agent.
PSA:	102.30000
LogP:	4.66890

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Chemistry

IUPAC Name: N-(4-Isothiocyanatophenyl)-4-nitroaniline
Molecular Formula: C₁₃H₉N₃O₂S
Molecular Weight: 271.29g/mol
Density:1.3g/cm³
Boiling Point: 469.7°C at 760mmHg
Flash Point: 237.9°C
Freely Rotating Bonds: 4
Polar Surface Area: 93.51 Å²
Index of Refraction: 1.654
Molar Refractivity: 76.45 cm³
Molar Volume: 208.3 cm³
Polarizability: 30.3 ×10^-24cm³
Surface Tension: 52.3 dyne/cm
Enthalpy of Vaporization: 73.21 kJ/mol
Vapour Pressure: 5.38E-09 mmHg at 25°C
The Cas Register Number of Amoscanate is 26328-53-0 .The chemical synonyms of Amoscanate (CAS No.26328-53-0) are Amoscanate ; Nithiocyanamine .The molecular structure of Amoscanate (CAS No.26328-53-0) is.

Uses

Amoscanate (CAS No.26328 - 53 - 0) is widely used to treat schistosomiasis and de-worming drugs in the nematode. It also can be used as pharmaceutical intermediates and spices industry.

Production

There are three kinds of synthesis methods:
(1) with right Dinitrofluorobenzene condensation with p-phenylenediamine derived from 4 - amino -4 '- nitro-diphenylamine, and then with the reaction of sulfur derived from phosgene.
(2) with 2 - chloro -5 - nitro - benzene sulfonic acid with the diamine condensation, was 4 - amino -4 '- nitrobenzene sulfonic acid, and then concentrated sulfuric acid hydrolysis, was 4 - amino -4' Nitrodiphenylamine, and then with the reaction of sulfur derived phosgene.
(3) from 4 - nitro--2 - acid -4 '- acetyl-amino-2-aniline by the concentrated sulfuric acid hydrolysis, was 4 - amino -4' - nitro-diphenylamine, and then with the reaction of sulfur derived from phosgene.

Toxicity Data With Reference

1.	dnr-esc 1 g/L	MUREAV Mutation Research 164 (1986),9.
2.	bfa-mus/omi 250 mg/kg	TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. 1 (1980),129.
3.	hma-mus/esc 250 mg/kg/3 H	MUREAV Mutation Research 164 (1986),9.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Mutation data reported. An anthelmintic agent.