Chlorodifluoroacetic anhydride

Base Information

• Chemical Name: Chlorodifluoroacetic anhydride
• CAS No.: 2834-23-3
• Molecular Formula: C4Cl2F4O3
• Molecular Weight: 242.942
• Hs Code.: 2915900090
• European Community (EC) Number: 220-603-4
• DSSTox Substance ID: DTXSID3062659
• Nikkaji Number: J236.406I
• Wikidata: Q81990174
• Mol file: 2834-23-3.mol

Synonyms:Chlorodifluoroacetic anhydride;2834-23-3;Acetic acid, chlorodifluoro-, anhydride;CHLORODIFLUOROACETICANHYDRIDE;(2-chloro-2,2-difluoroacetyl) 2-chloro-2,2-difluoroacetate;Chlorodifluoroacetic anhyride;Chloro(difluoro)acetic anhydride;EINECS 220-603-4;2-chloro-2,2-difluoroacetic anhydride;Acetic acid, 2-chloro-2,2-difluoro-, 1,1'-anhydride;C4Cl2F4O3;SCHEMBL317358;C4-Cl2-F4-O3;DTXSID3062659;AMY3629;chlorodifluoroacetic acid anhydride;Chlorodifluoroacetic anhydride, 98%;BBL101871;FD2050;MFCD00000774;STL555668;AKOS000121327;FT-0623646;Q-102556

Chemical Property of Chlorodifluoroacetic anhydride

Chemical Property:

• Vapor Pressure: 0.000439mmHg at 25°C
• Refractive Index: 1.347
• Boiling Point: 92.5 °C at 760 mmHg
• Flash Point: 25.9 °C
• PSA: 43.37000
• Density: 1.737 g/cm³
• LogP: 1.71940
• Sensitive.: Lachrymatory
• Water Solubility.: Slightly Soluble in water. (1.4 g/L) (25°C)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 241.9160619
• Heavy Atom Count: 13
• Complexity: 218

Purity/Quality:

98% ^*data from raw suppliers

Chlorodifluoroacetic Anhydride >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 23/24/25-34-21/22
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(=O)(C(F)(F)Cl)OC(=O)C(F)(F)Cl
• Uses: Chlorodifluoroacetic anhydride has been used:for dual element acetylation tagging derivatization of amines by using microwave sustained helium emission detectoras derivatization reagent in determination of estrone and 17β-estradiol in hair by GC-MS

Technology Process of Chlorodifluoroacetic anhydride

There total 3 articles about Chlorodifluoroacetic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-2,2-difluoroacetic acid (76-04-0) → chlorodifluoroacetic anhydride (2834-23-3)

Guidance literature:

With phosphorus pentoxide;

Reference yield:

Trifluoromethylsulfenyl chloride (421-17-0) + chloro-difluoro-acetic acid ; silver-salt (2923-14-0) → CF3SSO2CF3 + Bis(trifluoromethyl)disulfid (372-64-5) + chlorodifluoroacetic anhydride (2834-23-3)

Guidance literature:

Reference yield:

→ chlorodifluoroacetic anhydride (2834-23-3)

Guidance literature:

DOI:10.1007/BF00845743

upstream raw materials:

2-chloro-2,2-difluoroacetic acid

Trifluoromethylsulfenyl chloride

chloro-difluoro-acetic acid ; silver-salt

Downstream raw materials:

1,1,1,2,2,3,3,5,6,6,8,9,9,9-Tetradecafluoro-4,7-dioxa-5-(trifluoromethyl)-nonane

1,1,1,2,3,3-hexafluoro-2-(heptafluoropropoxy)-3-[(trifluorovinyl)oxy]propane

1-Chloro-1,1,3,4,4,4-hexafluoro-3-(1,1,2,3,3,3-hexafluoro-2-heptafluoropropyloxy-propoxy)-butan-2-one

5-Amino-4-chlorodifluoroacetyl-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole