NU 6027

Base Information

• Chemical Name: NU 6027
• CAS No.: 220036-08-8
• Molecular Formula: C11H17N5O2
• Molecular Weight: 251.288
• Mol file: 220036-08-8.mol

Synonyms:4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine;2,6-Diamino-4-cyclohexylmethoxy-5-nitroso pyrimidine;NU6027;NW1;1e1x;6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE;

Chemical Property of NU 6027

Chemical Property:

• Vapor Pressure: 4.1E-12mmHg at 25°C
• Melting Point: 252.5-253.7?°C(lit.)
• Boiling Point: 549.2oC at 760 mmHg
• PKA: 2.52±0.10(Predicted)
• Flash Point: 286oC
• PSA: 117.21000
• Density: 1.53g/cm3
• LogP: 2.50930
• Storage Temp.: 2-8°C
• Solubility.: DMSO: 15 mg/mL

Purity/Quality:

98%Min ^*data from raw suppliers

NU6027 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors

Technology Process of NU 6027

There total 2 articles about NU 6027 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

NU6034 (220036-14-6) → NU 6027 (220036-08-8)

Guidance literature:

With acetic acid; sodium nitrite; at 80 ℃;

DOI:10.1021/jm990628o

Reference yield:

cyclohexylmethyl alcohol (100-49-2) → NU 6027 (220036-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylsulfoxide / 80 °C

2: NaNO₂; aq. AcOH / 80 °C

With sodium hydride; acetic acid; sodium nitrite; In dimethyl sulfoxide;

DOI:10.1016/S0960-894X(02)00884-3

Reference yield: 89.0%

acetic anhydride (108-24-7) + NU 6027 (220036-08-8) → N,N'-[6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diyl]diacetamide (1470134-38-3)

Guidance literature:

at 50 ℃; for 20h;

DOI:10.1016/j.ejmech.2013.07.031

upstream raw materials:

NU₆₀₃₄

cyclohexylmethyl alcohol

Downstream raw materials:

5-(aminocarbonyl-NNO-azoxy)-6-(cyclohexylmethoxy)pyrimidine-2,4-diamine

7-(cyclohexylmethoxy)-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5-amine

6-cyclohexylmethoxy-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diamine

N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide

Refernces

• 1、 -. "Cyclin dependent kinase inhibitors". Page/Page column 9-10. . Retrieved 2010/02/05.
• 2、 Arris, Christine E.,Boyle, F. Thomas,Calvert, A. Hilary,Curtin, Nicola J.,Endicott, Jane A.,Garman, Elspeth F.,Gibson, Ashleigh E.,Golding, Bernard T.,Grant, Sharon,Griffin, Roger J.,Jewsbury, Philip,Johnson, Louise N.,Lawrie, Alison M.,Newell, David R.,Noble, Martin E. M.,Sausville, Edward A.,Schultz, Robert,Yu, Wyatt. "Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles". . p. 2797 - 2804. Retrieved 2007/10/03.