2-Bromo-6-iodophenol

Base Information

• Chemical Name: 2-Bromo-6-iodophenol
• CAS No.: 2040-86-0
• Molecular Formula: C6H4BrIO
• Molecular Weight: 298.90400
• Hs Code.: 2908199090
• Mol file: 2040-86-0.mol

Synonyms:PHENOL,2-BROMO-6-IODO;2-Brom-6-iod-phenol;

Chemical Property of 2-Bromo-6-iodophenol

Chemical Property:

• Melting Point: 63 °C
• Boiling Point: 214.4±25.0 °C(Predicted)
• PKA: 6.98±0.10(Predicted)
• PSA: 20.23000
• Density: 2.369±0.06 g/cm3(Predicted)
• LogP: 2.75930
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromo-6-iodophenol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-6-iodophenol

There total 12 articles about 2-Bromo-6-iodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-6-iodophenyl isopropylcarbamate (899427-32-8) → 2-bromo-6-iodophenol (2040-86-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 2h;

DOI:10.1055/s-2006-926462

Reference yield: 81.0%

2-hydroxybromobenzene (95-56-7) → 2-bromo-6-iodophenol (2040-86-0) + 2-bromo-4-iodo-phenol (133430-98-5)

Guidance literature:

With N-iodo-succinimide; toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 14h; regioselective reaction;

DOI:10.1016/j.tetlet.2009.03.128

Reference yield:

2-Iodophenol (533-58-4) → 2-bromo-6-iodophenol (2040-86-0) + 4-bromo-2-iodophenol (207115-22-8)

Guidance literature:

With N-Bromosuccinimide; iron(III) trifluoromethanesulfonate; In toluene; at 90 ℃; for 12h; Overall yield = 73 percent;

upstream raw materials:

2-Iodophenol

2-bromo-6-iodophenyl isopropylcarbamate

2-bromo-6-(trimethylsilyl)phenyl isopropylcarbamate

O-2-trimethylsilylphenyl N-isopropylcarbamate

Downstream raw materials:

(Z)-2-[2-benzyloxy-5-((S)-2-dibenzylamino-2-methoxycarbonyl-ethyl)-phenyl]-but-2-enoic acid 2-bromo-6-iodo-phenyl ester

Refernces

• 1、 -. "Halogenated method of aromatic compound". Paragraph 0208-0210. . Retrieved 2021/11/10.
• 2、 Bovonsombat, Pakorn,Leykajarakul, Juthamard,Khan, Chiraphorn,Pla-on, Kawin,Krause, Michael M.,Khanthapura, Pratheep,Ali, Rameez,Doowa, Niran. "Regioselective iodination of phenol and analogues using N-iodosuccinimide and p-toluenesulfonic acid". scheme or table. p. 2664 - 2667. Retrieved 2009/08/09.