2,4-Difluorophenylhydrazine hydrochloride

Base Information

• Chemical Name: 2,4-Difluorophenylhydrazine hydrochloride
• CAS No.: 51523-79-6
• Molecular Formula: C₆H₆F₂N₂*ClH
• Molecular Weight: 180.585
• Hs Code.: 29280000
• European Community (EC) Number: 627-383-2
• DSSTox Substance ID: DTXSID70369833
• Mol file: 51523-79-6.mol

Synonyms:51523-79-6;2,4-Difluorophenylhydrazine hydrochloride;(2,4-difluorophenyl)hydrazine Hydrochloride;2,4-difluorophenylhydrazine hcl;2,4-Difluorophenylhydrazine, HCl;(2,4-difluorophenyl)hydrazine;hydrochloride;1-(2,4-difluorophenyl)hydrazine hydrochloride;Hydrazine, (2,4-difluorophenyl)-, monohydrochloride;MFCD00013383;40594-29-4;2,4-Difluorohydrazinobenzene Hydrochloride;o-Nitroacetoacetanilide;2,4-difluorophenyl hydrazine hydrochloride;SCHEMBL176502;DTXSID70369833;AAMNNSRHAVREBH-UHFFFAOYSA-N;AKOS001476024;2.4-DIFLUOROPHENYLHYDRAZINE HCL;CS-W016004;GS-3467;SY004793;(2,4-difluorophenyl)hydrazineHydrochloride;2,4-difluoro-phenylhydrazine hydrochloride;(2,4-difluorophenyl)hydrazine.hydrochloride;A7595;AM20061218;D2698;FT-0610109;EN300-03626;2,4-Difluorophenylhydrazine hydrochloride, 97%;J-507220;Hydrazine, (2,4-difluorophenyl)-, hydrochloride (1:?);Z104474200

Chemical Property of 2,4-Difluorophenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Melting Point: 210 °C (dec.)(lit.)
• Boiling Point: 185.1 °C at 760 mmHg
• Flash Point: 65.7 °C
• PSA: 38.05000
• Density: 1.379g/cm3
• LogP: 2.82570
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 180.0265822
• Heavy Atom Count: 11
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluorophenylhydrazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1F)F)NN.Cl

Technology Process of 2,4-Difluorophenylhydrazine hydrochloride

There total 3 articles about 2,4-Difluorophenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

→ (2,4-difluorophenyl)hydrazinium chloride (40594-29-4,51523-79-6)

Guidance literature:

Reference yield:

2,4-difluorophenylamine (367-25-9,76563-56-9) → (2,4-difluorophenyl)hydrazinium chloride (40594-29-4,51523-79-6)

Guidance literature:

2,4-difluorophenylamine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With hydrogenchloride; tin(II) chloride dihdyrate; In water; for 2h;

DOI:10.1021/acs.jafc.0c07701

Reference yield:

2-oxo-propionic acid ethyl ester (617-35-6) + 2,4-difluorophenylamine (367-25-9,76563-56-9) → (2,4-difluorophenyl)hydrazinium chloride (40594-29-4,51523-79-6)

Guidance literature:

2,4-difluorophenylamine; With hydrogenchloride; sodium nitrite; In water; at -3 ℃; for 0.75h;

With tin(II) chloride dihdyrate; at 0 ℃;

2-oxo-propionic acid ethyl ester; With acetic acid; at 0 ℃; for 2h; Reflux;

DOI:10.1002/ejoc.202100021

upstream raw materials:

2-oxo-propionic acid ethyl ester

2,4-difluorophenylamine

Downstream raw materials:

2-(2,4-difluorophenylhydrazinomethylene)-5,5-dimethyl-1,3-cyclohexandione

3-(2,4-difluorophenylhydrazino)-5,5-dimethylcyclohex-2-en-1-one

1-(2,4-difluorophenyl)-1H-pyrazole

7-bromotryptamine hydrochloride

Refernces

• 1、 Zhou, Yuan,Zhang, Shasha,Cai, Meng,Wang, Kaixing,Feng, Jiangtao,Xie, Dan,Feng, Lingling,Peng, Hao,He, Hongwu. "Design, Synthesis, and Antifungal Activity of 2,6-Dimethyl-4-aminopyrimidine Hydrazones as PDHc-E1 Inhibitors with a Novel Binding Mode". . p. 5804 - 5817. Retrieved 2021/06/25.
• 2、 -. "3-Hydroxy carbazole derivatives". . . Retrieved 2008/06/13.