alpha,alpha'-Dimethylpiperazine-1,4-diethanol

Base Information

• Chemical Name: alpha,alpha'-Dimethylpiperazine-1,4-diethanol
• CAS No.: 7672-76-6
• Molecular Formula: C10H22N2O2
• Molecular Weight: 202.297
• Hs Code.: 2933599090
• European Community (EC) Number: 231-646-3
• NSC Number: 86980
• DSSTox Substance ID: DTXSID20998036
• Nikkaji Number: J307.918J
• Mol file: 7672-76-6.mol

Synonyms:7672-76-6;alpha,alpha'-Dimethylpiperazine-1,4-diethanol;EINECS 231-646-3;NSC 86980;1,4-Piperazinediethanol, alpha,alpha'-dimethyl-,;1,4-Piperazinediethanol, .alpha.,.alpha.'-dimethyl-;NSC86980;1-[4-(2-hydroxypropyl)piperazin-1-yl]propan-2-ol;NCIOpen2_005409;Oprea1_688158;Oprea1_789040;SCHEMBL636364;DTXSID20998036;NSC-86980;1,4-bis-(2-hydroxypropyl)piperazine;1,1'-(piperazine-1,4-diyl)dipropan-2-ol;1,1'-(Piperazine-1,4-diyl)di(propan-2-ol);1,1'-(Piperazine-1,4-diyl)bis(propan-2-ol)

Chemical Property of alpha,alpha'-Dimethylpiperazine-1,4-diethanol

Chemical Property:

• Boiling Point: 331.8oC at 760 mmHg
• Flash Point: 159.4oC
• PSA: 46.94000
• Density: 1.05g/cm3
• LogP: -0.75860
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 202.168127949
• Heavy Atom Count: 14
• Complexity: 140

Purity/Quality:

99% ^*data from raw suppliers

a1,a4-dimethyl-1,4-Piperazinediethanol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN1CCN(CC1)CC(C)O)O

Technology Process of alpha,alpha'-Dimethylpiperazine-1,4-diethanol

There total 6 articles about alpha,alpha'-Dimethylpiperazine-1,4-diethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

piperazine (110-85-0) + methyloxirane (75-56-9,16033-71-9) → N,N'-bis(2-hydoxypropyl)piperazine (7672-76-6)

Guidance literature:

In methanol; at 0 ℃; for 5h;

DOI:10.1007/s10973-017-6187-6

Reference yield: 60.0%

N,N'-bis(2,3-epoxypropyl)piperazine (2917-98-8) → N,N'-bis(2-hydoxypropyl)piperazine (7672-76-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Ambient temperature;

Reference yield:

N,N'-bis-allylpiperazine (13173-24-5) → 3-(1-piperazinyl)-1-propanol (5317-32-8) + 1-(1-piperazinyl)-2-propanol (1074-54-0) + N,N'-bis(2-hydoxypropyl)piperazine (7672-76-6) + 3-<4-(2-hydroxypropyl)-1-piperazinyl>-1-propanol (100500-98-9)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; diethylene glycol dimethyl ether; boron trifluoride diethyl etherate; dihydrogen peroxide; Product distribution;

upstream raw materials:

piperazine

methyloxirane

N,N'-bis-allylpiperazine

N,N'-bis(2,3-epoxypropyl)piperazine

Refernces

• 1、 Turkyilmaz, Murat. "Binuclear and mononuclear Cu(II) and Ni(II) complexes of tetra- and hexadentate ligands: Synthesis, antifungal activity, spectroscopic and thermal characterization". . p. 451 - 460. Retrieved 2017/06/20.
• 2、 Kafka, Stanislav,Ferles, Miloslav. "HYDROBORATION OF 1,4-DIALLYLPIPERAZINE". . p. 2275 - 2283. Retrieved 2007/10/02.