(2-Bromo-3-methylphenyl)methanol

Base Information

• Chemical Name: (2-Bromo-3-methylphenyl)methanol
• CAS No.: 168886-97-3
• Molecular Formula: C8H9BrO
• Molecular Weight: 201.063
• Hs Code.: 2906299090
• Mol file: 168886-97-3.mol

Synonyms:o-bromo-m-methylbenzyl alcohol;

Chemical Property of (2-Bromo-3-methylphenyl)methanol

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 277.315oC at 760 mmHg
• PKA: 14.22±0.10(Predicted)
• Flash Point: 121.516oC
• PSA: 20.23000
• Density: 1.481±0.06 g/cm3(Predicted)
• LogP: 2.24980
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

(2-Bromo-3-methylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-Bromo-3-methylphenyl)methanol

There total 3 articles about (2-Bromo-3-methylphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-methyl-2-bromobenzoic acid (53663-39-1) → (2-bromo-3-methylphenyl)methanol (168886-97-3)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 16.5h; Schlenk technique; Reflux;

DOI:10.1246/cl.171211

Reference yield: 95.0%

2-bromo-3-methylbenzoic acid ethyl ester (155694-83-0) → (2-bromo-3-methylphenyl)methanol (168886-97-3)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 91.1%

methyl 2-bromo-3-methylbenzoate (131001-86-0) → (2-bromo-3-methylphenyl)methanol (168886-97-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

upstream raw materials:

3-methyl-2-bromobenzoic acid

methyl 2-bromo-3-methylbenzoate

2-bromo-3-methylbenzoic acid ethyl ester

Downstream raw materials:

2-bromo-3-methyl-benzaldehyde

C₁₁H₁₁BrO₂

C₁₂H₁₄BrN₃O

2-bromo-1-(methoxymethyl)-3-methylbenzene

Refernces

• 1、 -. "APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF". . . Retrieved 2019/02/25.
• 2、 Yonekawa, Izumi,Mutoh, Katsuya,Kobayashi, Yoichi,Abe, Jiro. "Structurally and electronically modulated spin interaction of transient biradicals in two photon-gated stepwise photochromism". . p. 290 - 301. Retrieved 2018/03/23.