N'-((Dimethylamino)methylene)-N,N-dimethylformohydrazonamide dihydrochloride

Base Information

• Chemical Name: N'-((Dimethylamino)methylene)-N,N-dimethylformohydrazonamide dihydrochloride
• CAS No.: 16227-06-8
• Molecular Formula: C6H14N4.2ClH
• Molecular Weight: 215.12400
• Mol file: 16227-06-8.mol

Synonyms:

Chemical Property of N'-((Dimethylamino)methylene)-N,N-dimethylformohydrazonamide dihydrochloride

Chemical Property:

• Melting Point: 251 °C
• PSA: 31.20000
• LogP: 1.68520

Purity/Quality:

99% ^*data from raw suppliers

N''-((Dimethylamino)methylene)-N,N-dimethylformohydrazonamideDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N'-((Dimethylamino)methylene)-N,N-dimethylformohydrazonamide dihydrochloride

There total 7 articles about N'-((Dimethylamino)methylene)-N,N-dimethylformohydrazonamide dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → {N'-[(dimethylamino)methylene]-N,N-dimethylhydrazonoformamide dihydrochloride} (16227-06-8)

Guidance literature:

N,N-dimethyl-formamide; With thionyl chloride; at 0 - 20 ℃; for 28h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 20 ℃; for 36h;

DOI:10.1016/j.cclet.2020.09.029

Reference yield: 95.0%

diformylhydrazine (628-36-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (1E,N’E)-N’-((dimethylamino)methylene)-N,N-dimethylformohydrazonamide dihydrochloride (16227-06-8)

Guidance literature:

With thionyl chloride; at 10 ℃; for 48h;

Reference yield: 91.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-dimethylformamide azine dihydrochloride (16227-06-8)

Guidance literature:

N,N-dimethyl-formamide; With thionyl chloride; oxalyl dichloride; for 24h;

With hydrazine hydrate; at 20 ℃; for 48h; Further stages.;

DOI:10.1055/s-2007-983896

upstream raw materials:

diformylhydrazine

N,N-dimethyl-formamide

N,N-Dimethylcarbamoyl chloride

Downstream raw materials:

4,4'-bi-1,2,4-triazole

4-[4-(trifluoromethyl)phenyl]-4H-1,2,4-triazole

4-(2-nitrophenyl)-4H-1,2,4-triazole

5-(4H-1,2,4-triazol-4-yl) benzene-1,3-dicarboxylic acid

Refernces

• 1、 Lu, Feipeng,Wang, Engyu,Huang, Jinglun,Huang, Ming,Nie, Fude,Chen, Fu-Xue. "The synthesis, property and reduction of high-nitrogen compound 3,3′,5,5′-tetraazido-4,4′-bis(1,2,4-triazole)". . p. 445 - 452. Retrieved 2016.
• 2、 Leiter, Josef,Reichert, Dennis,Rentmeister, Andrea,Micura, Ronald. "Practical Synthesis of Cap-4 RNA". . p. 265 - 271. Retrieved 2019/11/16.
• 3、 -. "METHODS AND CATALYSTS FOR CONVERTING METHANE TO METHANOL". Paragraph 0154. . Retrieved 2018/06/15.