2'-Hydroxyflavanone

Base Information

• Chemical Name: 2'-Hydroxyflavanone
• CAS No.: 17348-76-4
• Molecular Formula: C15H12 O3
• Molecular Weight: 240.258
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID60938395
• Nikkaji Number: J285.124E
• Pharos Ligand ID: X2BAB6PTF4HZ
• Metabolomics Workbench ID: 74396
• ChEMBL ID: CHEMBL75897
• Mol file: 17348-76-4.mol

Synonyms:2'-hydroxyflavanone;2'-OH flavanone

Chemical Property of 2'-Hydroxyflavanone

Chemical Property:

• Vapor Pressure: 0.748mmHg at 25°C
• Melting Point: 164.0 to 168.0 °C
• Boiling Point: 184°C at 760 mmHg
• Flash Point: 65.1°C
• PSA: 46.53000
• Density: 1.397g/cm³
• LogP: 3.09870
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 240.078644241
• Heavy Atom Count: 18
• Complexity: 315

Purity/Quality:

98%,99%, ^*data from raw suppliers

2''-Hydroxyflavanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C(OC2=CC=CC=C2C1=O)C3=CC=CC=C3O

Technology Process of 2'-Hydroxyflavanone

There total 15 articles about 2'-Hydroxyflavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C17H16O4 → 2'-hydroxyflavanone (17348-76-4)

Guidance literature:

With sulfuric acid; acetic acid; at 20 ℃; for 36h;

DOI:10.1016/j.ejmech.2018.08.069

Reference yield: 94.0%

trans-2,2'-dihydroxychalcone (15131-80-3,34000-30-1) → 2'-hydroxyflavanone (17348-76-4)

Guidance literature:

With water; triethylamine; In ethanol; for 8h; Reflux;

DOI:10.1134/S1070363219070028

Reference yield: 66.0%

2'-hydroxy-2-methoxymethoxychalcone → trans-2,2'-dihydroxychalcone (15131-80-3,34000-30-1) + 2'-hydroxyflavanone (17348-76-4)

Guidance literature:

With hydrogenchloride; In methanol; at 100 ℃; for 0.25h;

DOI:10.1248/cpb.53.547

upstream raw materials:

trans-2,2'-dihydroxychalcone

2-methyl-benzyl alcohol

o-hydroxyacetophenone

2-(methoxymethoxy)benzaldehyde

Downstream raw materials:

2-[3-(2-hydroxyphenyl)propyl]phenol

4-[1,3-Bis-(2-hydroxy-phenyl)-propyl]-2-[3-(2-hydroxy-phenyl)-propyl]-phenol

2-(4-oxochroman-2-yl)phenyl phenylcarbamate

C₁₆H₁₅N₃O₃

Refernces

• 1、 Cho, Yang Yil,Jang, Hyu Jeong,Kim, Dong Hwan,Kim, Nam Yong,Kim, Nam-Jung,Kim, Young Min,Lee, Soo Jin,Lee, Yong Sup,Park, Boyoung Y.,Son, Seung Hwan,Yoo, Hyung-Seok. "Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot β-Arylation of Chromanones with Arylboronic Acids". . p. 10012 - 10023. Retrieved 2019/08/30.
• 2、 Anand, Preet,Singh, Baldev. "Synthesis and evaluation of novel carbamate-substituted flavanone derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents". . p. 1648 - 1659. Retrieved 2013/07/26.