N-(4-Phenoxyphenyl)acetamide

Base Information

• Chemical Name: N-(4-Phenoxyphenyl)acetamide
• CAS No.: 6312-87-4
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• European Community (EC) Number: 663-359-8
• NSC Number: 40576
• UNII: CSE7U756DE
• DSSTox Substance ID: DTXSID20212461
• Nikkaji Number: J673.547I
• Wikidata: Q83087597
• ChEMBL ID: CHEMBL1730562
• Mol file: 6312-87-4.mol

Synonyms:N-(4-Phenoxyphenyl)acetamide;6312-87-4;N-(4-Phenoxy-phenyl)-acetamide;CCRIS 7394;CSE7U756DE;NSC-40576;NSC40576;acetylaminodiphenyl ether;CBMicro_013346;UNII-CSE7U756DE;Oprea1_118739;Oprea1_181639;4'-PHENOXYACETANILIDE;MLS000766059;SCHEMBL171438;CHEMBL1730562;DTXSID20212461;Acetamide, N-(4-phenoxyphenyl)-;HMS1672I12;HMS2744D10;SMSF0004364;MFCD00442086;NSC 40576;STK018421;AKOS000478782;CB04396;DS-7047;SB79858;NCGC00245509-01;AC-21009;SMR000279765;BIM-0013400.P001;LS-188377;CS-0153971;4-(ACETYLAMINO)-1,1'-DIPHENYL ETHER;C75966;A868236;AA-504/32989002;BRD-K65607646-001-07-4;Z28286044

Chemical Property of N-(4-Phenoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 5.87E-07mmHg at 25°C
• Melting Point: 106-107 °C
• Refractive Index: 1.61
• Boiling Point: 410.8 °C at 760 mmHg
• PKA: 14.36±0.70(Predicted)
• Flash Point: 202.2 °C
• Density: 1.176 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 227.094628657
• Heavy Atom Count: 17
• Complexity: 241

Purity/Quality:

99%min ^*data from raw suppliers

N-(4-Phenoxyphenyl)acetamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)OC2=CC=CC=C2

Technology Process of N-(4-Phenoxyphenyl)acetamide

There total 22 articles about N-(4-Phenoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic anhydride (108-24-7) + 4-phenoxyanilin (139-59-3) → p-phenoxyacetanilide (6312-87-4)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1021/jm9905007

Reference yield: 98.0%

1-(4-phenoxyphenyl)ethan-1-one oxime (6337-25-3) → p-phenoxyacetanilide (6312-87-4)

Guidance literature:

1-(4-phenoxyphenyl)ethan-1-one oxime; With fluorosulfonyl fluoride; triethylamine; In acetonitrile; at 20 ℃;

With hydrogenchloride; In water; acetonitrile; at 20 ℃;

DOI:10.1002/ejoc.201900844

Reference yield: 96.0%

tungsten hexacarbonyl (14040-11-0) + 4-nitrophenyl phenyl ether (620-88-2) + carbonic acid dimethyl ester (616-38-6) → p-phenoxyacetanilide (6312-87-4)

Guidance literature:

With di(rhodium)tetracarbonyl dichloride; 1,3-bis-(diphenylphosphino)propane; sodium phosphate; sodium iodide; In water; at 120 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1039/d1cc00047k

upstream raw materials:

4-phenoxyacetophenone

4-nitrophenyl phenyl ether

acetic acid

1-(4-phenoxy-phenyl)-ethanone oxime

Downstream raw materials:

N-(2-nitro-4-phenoxyphenyl)acetamide

N-ethyl-4-phenoxyaniline

4-phenoxyanilin

3,5-diiodo-2-methoxy-N-methyl-N-(4-phenoxyphenyl)benzamide

Refernces

• 1、 -. "Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction". Paragraph 0134-0138; 0140. . Retrieved 2021/05/29.
• 2、 Tang, Li,Wang, Zhi-Lv,Wan, Hai-Lan,He, Yan-Hong,Guan, Zhi. "Visible-light-induced Beckmann rearrangement by organic photoredox catalysis". supporting information. p. 6182 - 6186. Retrieved 2020/09/01.