7-epi-10-Deacetyl CephaloMannine

Base Information

• Chemical Name: 7-epi-10-Deacetyl CephaloMannine
• CAS No.: 78479-12-6
• Molecular Formula: C₄₃H₅₁NO₁₃
• Molecular Weight: 789.877
• Mol file: 78479-12-6.mol

Synonyms:

Chemical Property of 7-epi-10-Deacetyl CephaloMannine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-epi-10-Deacetyl CephaloMannine

There total 8 articles about 7-epi-10-Deacetyl CephaloMannine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.92%

2'-tert-butyldimethylsilyl-10-deacetyl-cephalomannine → 10-deacetyl-cephalomannine (78479-12-6)

Guidance literature:

With pyridine; hydrogen fluoride; In acetonitrile; at 20 ℃; for 24h;

Reference yield: 88.0%

cephalomannine (71610-00-9) → 10β-deacetylcephalomannine (76429-85-1,78479-12-6)

Guidance literature:

With dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/ejoc.200300376

Reference yield: 69.0%

C55H67Cl6NO17Si → 10-deacetyltaxol B (78479-12-6)

Guidance literature:

C₅₅H₆₇Cl₆NO₁₇Si; With acetic acid; zinc; In methanol; at 23 ℃; for 1.5h;

With pyridine; hydrogen fluoride; In acetonitrile; for 1.5h; Temperature; Cooling with ice;

upstream raw materials:

Cephalomannine

cephalomannine

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

10-deacetyl-7,10-diTroc-baccatin III

Refernces

• 1、 -. "CEPHALOMANNINE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION AND USE THEREOF". Page/Page column 5. . Retrieved 2011/04/13.
• 2、 Appendino, Giovanni,Noncovich, Alain,Bettoni, Piergiorgio,Dambruoso, Paolo,Sterner, Olov,Fontana, Gabriele,Bombardelli, Ezio. "The Reductive Fragmentation of 7-Hydroxy-9,10-dioxotaxoids". . p. 4422 - 4431. Retrieved 2007/10/03.