3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid o-aminoanilide

Base Information

• Chemical Name: 3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid o-aminoanilide
• CAS No.: 92983-92-1
• Molecular Formula: C₁₈H₁₈N₄O₄
• Molecular Weight: 354.365
• Mol file: 92983-92-1.mol

Synonyms:

Chemical Property of 3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid o-aminoanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid o-aminoanilide

There total 5 articles about 3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid o-aminoanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-diamino-benzene (95-54-5) + 3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid γ-lactone (92983-93-2) → 3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid o-aminoanilide (92983-92-1)

Guidance literature:

In methanol; at 40 ℃; for 2h;

DOI:10.1016/0008-6215(84)85209-X

Reference yield:

isoascorbic acid (89-65-6,98966-42-8) → 3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid o-aminoanilide (92983-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzoquinone / methanol; H₂O / 2 h / 20 °C

2: methanol; H₂O / 0.03 h / microwave irradiation

With p-benzoquinone; In methanol; water;

DOI:10.1080/07328300701252359

Reference yield:

1,2-diamino-benzene (95-54-5) + isoascorbic acid (89-65-6,98966-42-8) → 3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid o-aminoanilide (92983-92-1)

Guidance literature:

With p-benzoquinone; Yield given. Multistep reaction; 1.) methanol/water, 2 h, room temperature, 2.) methanol/water, 2 h, 40 deg C;

DOI:10.1016/0008-6215(84)85209-X

upstream raw materials:

1,2-diamino-benzene

isoascorbic acid

3-(D-erythro-glycerol-1-yl)quinoxaline-2-carboxylic acid γ-lactone

p-benzoquinone

Downstream raw materials:

3-((1S,2R)-1,2,3-Trihydroxy-propyl)-quinoxaline-2-carboxylic acid N'-(2,4-dinitro-phenyl)-hydrazide

3-((1S,2R)-1,2,3-Trihydroxy-propyl)-quinoxaline-2-carboxylic acid N'-(4-nitro-phenyl)-hydrazide

3-(D-erythro-2,3-di-O-benzoylglycerol-1-yl)quinoxaline-2-carboxylic γ-lactone

Toluene-4-sulfonic acid (R)-2-hydroxy-2-((S)-3-oxo-1,3-dihydro-furo[3,4-b]quinoxalin-1-yl)-ethyl ester

Refernces

• 1、 Sekily, Mohamed Ali El,Mancy, Sohila,Fahmy, Kamal. "Some quinoxaline derivatives from dehydro-D-arabino-ascorbic acid". . p. 324 - 328. Retrieved 2007/10/02.