1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol

Base Information

• Chemical Name: 1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol
• CAS No.: 854460-29-0
• Molecular Formula: C₂₂H₃₀O₁₀
• Molecular Weight: 454.474
• Mol file: 854460-29-0.mol

Synonyms:

Chemical Property of 1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol

There total 3 articles about 1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-bis-(4-acetoxy-3,5-dimethoxy-phenyl)-tetrahydro-furo[3,4-c]furan-1,4-dione (66701-59-5) → 1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol (854460-29-0)

Guidance literature:

With tetrahydrofuran; lithium aluminium tetrahydride;

Reference yield:

trans-3,5-dimethoxy-4-hydroxycinnamic acid (530-59-6,7362-37-0) → 1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol (854460-29-0)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol; aqueous iron (III)-chloride-solution; oxygen / Behandeln des Reaktionsprodukts mit wss. Salzsaeure

2: pyridine

3: LiAlH₄; THF

With tetrahydrofuran; pyridine; methanol; lithium aluminium tetrahydride; oxygen; iron(III) chloride;

Reference yield:

3,6-bis(4-hydroxy-3,5-dimethoxyphenyl)tetrahydrofuro[3,4-c]furan-1,4-dione (65167-29-5) → 1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol (854460-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: LiAlH₄; THF

With tetrahydrofuran; pyridine; lithium aluminium tetrahydride;

upstream raw materials:

3,6-bis-(4-acetoxy-3,5-dimethoxy-phenyl)-tetrahydro-furo[3,4-c]furan-1,4-dione

trans-3,5-dimethoxy-4-hydroxycinnamic acid

3,6-bis(4-hydroxy-3,5-dimethoxyphenyl)tetrahydrofuro[3,4-c]furan-1,4-dione

Downstream raw materials:

(+/-)-1c,4c-Bis-(4-acetoxy-3,5-dimethoxy-phenyl)-(3ar,6ac)-tetrahydro-furo[3,4-c]furan