5-carbomethoxy-2-trans-allylcyclohexanol

Base Information

• Chemical Name: 5-carbomethoxy-2-trans-allylcyclohexanol
• CAS No.: 102437-53-6
• Molecular Formula: C₁₁H₁₈O₃
• Molecular Weight: 198.262
• Mol file: 102437-53-6.mol

Synonyms:

Chemical Property of 5-carbomethoxy-2-trans-allylcyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-carbomethoxy-2-trans-allylcyclohexanol

There total 8 articles about 5-carbomethoxy-2-trans-allylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Carboxyphenol (99-06-9) → 5-carbomethoxy-2-cis-allylcyclohexanol (102437-53-6,102437-54-7)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 5percent Rh/Al₂O₃ / methanol / 24 h / 25 °C / 2585.7 Torr

2: H₂SO₄ / 20 h / Heating

3: Celite, pyridinium chlorochromate (PCC) / CH₂Cl₂ / 3 h / 25 °C

4: 1.) 2,2-dimethoxypropane, p-toluenesulfonic acid, 2.) NaBH₄ / 1.) benzene, reflux, 2.) methanol, 0 deg C, 30 min

With sodium tetrahydroborate; Celite; sulfuric acid; hydrogen; toluene-4-sulfonic acid; 2,2-dimethoxy-propane; pyridinium chlorochromate; Rh/Al₂O₃; In methanol; dichloromethane;

DOI:10.1021/jo00362a012

Reference yield:

3-Carboxyphenol (99-06-9) → 5-carbomethoxy-2-trans-allylcyclohexanol (102437-53-6,102437-54-7)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 5percent Rh/Al₂O₃ / methanol / 24 h / 25 °C / 2585.7 Torr

2: H₂SO₄ / 20 h / Heating

3: Celite, pyridinium chlorochromate (PCC) / CH₂Cl₂ / 3 h / 25 °C

4: 1.) 2,2-dimethoxypropane, p-toluenesulfonic acid, 2.) NaBH₄ / 1.) benzene, reflux, 2.) methanol, 0 deg C, 30 min

With sodium tetrahydroborate; Celite; sulfuric acid; hydrogen; toluene-4-sulfonic acid; 2,2-dimethoxy-propane; pyridinium chlorochromate; Rh/Al₂O₃; In methanol; dichloromethane;

DOI:10.1021/jo00362a012

Reference yield:

methyl 3-hydroxycyclohexanecarboxylate (37722-82-0) → 5-carbomethoxy-2-cis-allylcyclohexanol (102437-53-6,102437-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Celite, pyridinium chlorochromate (PCC) / CH₂Cl₂ / 3 h / 25 °C

2: 1.) 2,2-dimethoxypropane, p-toluenesulfonic acid, 2.) NaBH₄ / 1.) benzene, reflux, 2.) methanol, 0 deg C, 30 min

With sodium tetrahydroborate; Celite; toluene-4-sulfonic acid; 2,2-dimethoxy-propane; pyridinium chlorochromate; In dichloromethane;

DOI:10.1021/jo00362a012

upstream raw materials:

3-oxo-cyclohexanecarboxylic acid methyl ester

allyl alcohol

methyl 3-hydroxycyclohexanecarboxylate

3-hydroxycyclohexane-1-carboxylic acid

Downstream raw materials:

5-carbomethoxy-2-trans-(3-hydroxypropyl)cyclohexanol

methyl 4-(3-hydroxypropyl)-3-(tosyloxy)cyclohexanecarboxylate

methyl 4-allyl-3-(tosyloxy)cyclohexanecarboxylate

Refernces