(3,4-dimethylphenyl)hydrazineHydrochloride

Base Information

• Chemical Name: (3,4-dimethylphenyl)hydrazineHydrochloride
• CAS No.: 60481-51-8
• Molecular Formula: C₈H₁₂N₂*ClH
• Molecular Weight: 172.658
• Hs Code.: 29280000
• Mol file: 60481-51-8.mol

Synonyms:AKOS015890160;(3,4-dimethylphenyl)hydrazineHydrochloride

Chemical Property of (3,4-dimethylphenyl)hydrazineHydrochloride

Chemical Property:

• Appearance/Colour: White to pink or beige-brown powder
• Vapor Pressure: 0.0196mmHg at 25°C
• Melting Point: 195-200 °C(lit.)
• Refractive Index: 1.607
• Boiling Point: 252.2oC at 760 mmHg
• Flash Point: 122.2oC
• PSA: 38.05000
• Density: 1.058g/cm³
• LogP: 3.16430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 172.0767261
• Heavy Atom Count: 11
• Complexity: 103

Purity/Quality:

99.9% ^*data from raw suppliers

3,4-DimethylphenylhydrazineHydrochlorideSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].CC1=C(C=C(C=C1)NN)C.[Cl-]
• Uses: 3,4-Dimethylphenylhydrazine hydrochloride, is used as a reactant with ethyl 3-ethoxy-2-ethoxycarbonylprop-2-enoate to produce 2-(3,4-dimethyl-phenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester. This reaction will need reagent K2CO3, and the menstruum ethanol.

Technology Process of (3,4-dimethylphenyl)hydrazineHydrochloride

There total 2 articles about (3,4-dimethylphenyl)hydrazineHydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

4-amino-o-xylene (95-64-7) → 3,4-dimethylphenylhydrazine hydrochloride (60481-51-8,86746-50-1)

Guidance literature:

With hydrogenchloride; sodium hydrogensulfite; sodium hydroxide; sodium nitrite; In water; at 5 - 85 ℃; Temperature;

Reference yield: 78.0%

4-bromo-o-xylene (583-71-1) → 3,4-dimethylphenylhydrazine hydrochloride (60481-51-8,86746-50-1)

Guidance literature:

4-bromo-o-xylene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 100.0%

trimethylacetylacetonitrile (59997-51-2) + 3,4-dimethylphenylhydrazine hydrochloride (60481-51-8,86746-50-1) → 5-tert-butyl-2-(3,4-dimethyl-phenyl)-2H-pyrazol-3-ylamine (1025893-78-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 18h; Reflux;

upstream raw materials:

4-amino-o-xylene

4-bromo-o-xylene

Downstream raw materials:

2-(3,4-dimethylphenyl)-2,4-dihydropyrazol-3-one

2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

1-(3,4-dimethylphenyl)-5-oxo-4,5-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester

4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-1-(3,4-dimethylphenyl)-1,2-dihydro-3H-pyrazol-3-one

Refernces

• 1、 -. "A 3 - methyl -1 - (3, 4 - dimethyl phenyl) -2 - pyrazoline -5 - one hydrochloride preparation method". Paragraph 0020; 0028; 0029. . Retrieved 2019/03/31.
• 2、 -. "Double-ring substituted pyrazolone azo derivatives, their preparation and use (by machine translation)". Paragraph 0095; 0105; 0106; 0107. . Retrieved 2017/01/02.