Ethyl 2-(4-phenoxyphenyl)lactate

Base Information

• Chemical Name: Ethyl 2-(4-phenoxyphenyl)lactate
• CAS No.: 132584-17-9
• Molecular Formula: C₁₇H₁₈O₄
• Molecular Weight: 286.328
• European Community (EC) Number: 429-220-9,603-636-2
• DSSTox Substance ID: DTXSID801035866
• Mol file: 132584-17-9.mol

Synonyms:ethyl 2-(4-phenoxyphenyl)lactate;SCHEMBL7756224;ethyl 2-(4phenoxyphenyl)lactate;NFJAMPAQUJUQEH-UHFFFAOYSA-N;DTXSID801035866;132584-17-9

Chemical Property of Ethyl 2-(4-phenoxyphenyl)lactate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 286.12050905
• Heavy Atom Count: 21
• Complexity: 330

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C(C)(C1=CC=C(C=C1)OC2=CC=CC=C2)O

Technology Process of Ethyl 2-(4-phenoxyphenyl)lactate

There total 2 articles about Ethyl 2-(4-phenoxyphenyl)lactate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-oxo-propionic acid ethyl ester (617-35-6) + diphenylether (101-84-8) → ethyl 2-hydroxy-2-(4-phenoxyphenyl)propionate (132584-17-9,177746-82-6,177746-83-7)

Guidance literature:

With aluminum (III) chloride; sodium carbonate; In dichloromethane; at -9 - -8 ℃; Reagent/catalyst; Solvent;

Reference yield: 52.0%

2-oxo-propionic acid ethyl ester (617-35-6) + 4-Bromodiphenyl ether (101-55-3) → ethyl 2-hydroxy-2-(4-phenoxyphenyl)propionate (132584-17-9,177746-82-6,177746-83-7)

Guidance literature:

4-Bromodiphenyl ether; With iodine; magnesium; In tetrahydrofuran; for 1h; Reflux;

2-oxo-propionic acid ethyl ester; In tetrahydrofuran; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; Cooling with ice;

DOI:10.1016/j.bmc.2011.06.008

Reference yield:

1,1'-carbonyldiimidazole (530-62-1) + ethyl 2-hydroxy-2-(4-phenoxyphenyl)propionate (132584-17-9,177746-82-6,177746-83-7) → imidazole-1-carboxylic acid 1-ethoxycarbonyl-1-(4-phenoxy-phenyl)-ethyl ester

Guidance literature:

In dichloromethane; at 25 ℃; for 19h;

DOI:10.1002/1526-4998(200102)57:2<143::AID-PS282>3.0.CO;2-8

upstream raw materials:

2-oxo-propionic acid ethyl ester

4-Bromodiphenyl ether

diphenylether

Downstream raw materials:

famoxadone

ethyl 2-(p-nitrophenoxycarbonyloxy)-2-(4-phenoxyphenyl)propionate

5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)oxazolidine-2,4-dione

C₂₂H₁₆BrFN₂O₄

Refernces

• 1、 Wang, Fu,Li, Hui,Wang, Le,Yang, Wen-Chao,Wu, Jia-Wei,Yang, Guang-Fu. "Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2, 4-diones as potent cytochrome bc1 complex inhibitors". experimental part. p. 4608 - 4615. Retrieved 2011/09/19.