1-Chloro-2-methoxynaphthalene

Base Information

• Chemical Name: 1-Chloro-2-methoxynaphthalene
• CAS No.: 13101-92-3
• Molecular Formula: C11H9ClO
• Molecular Weight: 192.645
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID70468658
• Nikkaji Number: J876.227I
• Wikidata: Q82295980
• Mol file: 13101-92-3.mol

Synonyms:1-Chloro-2-methoxynaphthalene;13101-92-3;Naphthalene, 1-chloro-2-methoxy-;1-chloro-2-methoxy-naphthalene;1- chloro-2-methoxynaphthalene;SCHEMBL2327449;DTXSID70468658;RPURXCRKUMBNJK-UHFFFAOYSA-N;CS-0432856;FT-0727102;A18156;E85057;2,2 inverted exclamation mark -(1,3-Propanediyldioxy)bisbenzaldehyde

Chemical Property of 1-Chloro-2-methoxynaphthalene

Chemical Property:

• PSA: 9.23000
• LogP: 3.50180
• Storage Temp.: 2-8°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 192.0341926
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Chloro-2-methoxynaphthalene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C2=CC=CC=C2C=C1)Cl

Technology Process of 1-Chloro-2-methoxynaphthalene

There total 21 articles about 1-Chloro-2-methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Methoxynaphthalene (93-04-9) → 1-chloro-2-methoxynaphthalene (13101-92-3)

Guidance literature:

With hydrogenchloride; 2-nitropropane; pyridine hydrochloride; for 1h; Heating;

Reference yield: 93.0%

1-bromo-2-methoxynaphthalene (3401-47-6) → 1-chloro-2-methoxynaphthalene (13101-92-3)

Guidance literature:

With copper(l) chloride; In N,N-dimethyl-formamide; Reflux; Inert atmosphere;

DOI:10.1002/chem.201102442

Reference yield: 52.0%

2-methoxy-1-naphthaldehyde (5392-12-1) → formic acid (64-18-6) + 1-chloro-2-methoxynaphthalene (13101-92-3)

Guidance literature:

With hydrogenchloride; potassium chloride; dihydrogen peroxide; vanadia; In water; acetone; at 20 ℃; for 12h; Reagent/catalyst;

DOI:10.1002/cctc.201600843

upstream raw materials:

N-chloro-succinimide

2-Methoxynaphthalene

1-chloro-5,5-dimethylhydantoin

1,3-dichloro-5,5-dimethylhydantoin

Downstream raw materials:

1-(5-chloro-6-methoxynaphthalen-2-yl)ethan-1-one

(R)-2,2'-dimethoxy-1,1'-dinaphthyl

(S)-2,2'-dimethoxy-1,1'-dinaphthyl

6-bromo-1-chloro-2-methoxynaphthalene

Refernces

• 1、 Ackermann, Lutz,Jacob, Nicolas,Oliveira, Jo?o C. A.,Wencel-Delord, Joanna,Zaid, Yassir. "Cobalt-Catalyzed Enantioselective C–H Arylation of Indoles". supporting information. p. 798 - 806. Retrieved 2022/02/03.
• 2、 Ji, Yuan-Zhao,Li, Hui-Jing,Wang, Yi-Ruo,Wu, Yan-Chao,Zhang, Zheng-Yan. "Sulfoxide-Promoted Chlorination of Indoles and Electron-Rich Arenes with Chlorine as Nucleophile". supporting information. . Retrieved 2020/02/05.